Intergenerational transmission of ADHD behaviors: genetic and environmental pathways.

Autor:	Kleppesto TH; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway., Eilertsen EM; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., van Bergen E; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Research Institute LEARN!, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Sunde HF; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Zietsch B; Centre for Psychology and Evolution, School of Psychology, University of Queensland, Brisbane, Australia., Nordmo M; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Educational Science, University of South-Eastern Norway, Notodden, Norway., Eftedal NH; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Havdahl A; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Nic Waals Institute, Spångbergveien 25, 0853 Oslo, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Ystrom E; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway., Torvik FA; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2024 May; Vol. 54 (7), pp. 1309-1317. Date of Electronic Publication: 2023 Nov 03.
DOI:	10.1017/S003329172300315X
Abstrakt:	Background: We investigate if covariation between parental and child attention-deficit hyperactivity disorder (ADHD) behaviors can be explained by environmental and/or genetic transmission. Methods: We employed a large children-of-twins-and-siblings sample ( N = 22 276 parents and 11 566 8-year-old children) of the Norwegian Mother, Father and Child Cohort Study. This enabled us to disentangle intergenerational influences via parental genes and parental behaviors (i.e. genetic and environmental transmission, respectively). Fathers reported on their own symptoms and mothers on their own and their child's symptoms. Results: Child ADHD behaviors correlated with their mother's (0.24) and father's (0.10) ADHD behaviors. These correlations were largely due to additive genetic transmission. Variation in children's ADHD behaviors was explained by genetic factors active in both generations (11%) and genetic factors specific to the children (46%), giving a total heritability of 57%. There were small effects of parental ADHD behaviors (2% environmental transmission) and gene-environment correlation (3%). The remaining variability in ADHD behaviors was due to individual-specific environmental factors. Conclusions: The intergenerational resemblance of ADHD behaviors is primarily due to genetic transmission, with little evidence for parental ADHD behaviors causing children's ADHD behaviors. This contradicts theories proposing environmental explanations of intergenerational transmission of ADHD, such as parenting theories or psychological life-history theory.
Databáze:	MEDLINE
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