Pathophysiology of bradykinin and histamine mediated angioedema.
| Autor: | Lima H; LEADER Research Inc., Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada., Zheng J; McMaster University, Hamilton, ON, Canada., Wong D; Division of Clinical Immunology and Allergy, Department of Medicine, University of Toronto, Toronto, ON, Canada., Waserman S; Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada., Sussman GL; Department of Medicine and Division of Clinical Immunology & Allergy, University of Toronto, Toronto, ON, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in allergy [Front Allergy] 2023 Oct 18; Vol. 4, pp. 1263432. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2023). |
| DOI: | 10.3389/falgy.2023.1263432 |
| Abstrakt: | Angioedema is characterized by swelling localized to the subcutaneous and submucosal tissues. This review provides an overview of angioedema, including the different types, triggers, and underlying pathophysiologic mechanisms. Hereditary and acquired angioedema are caused by dysregulation of the complement and kinin pathways. In contrast, drug-induced and allergic angioedema involve the activation of the immune system and release of vasoactive mediators. Recent advances in the understanding of the pathophysiology of angioedema have led to the development of targeted therapies, such as monoclonal antibodies, bradykinin receptor antagonists, and complement inhibitors, which promise to improve clinical outcomes in patients with this challenging condition. To accurately diagnose and manage angioedema, an understanding of this condition's complex and varied pathophysiology is both necessary and critical. Competing Interests: HL was employed by LEADER Research Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor JP declared a shared research group UCARE networks of excellence with the author GS at the time of the review. (© 2023 Lima, Zheng, Wong, Waserman and Sussman.) |
| Databáze: | MEDLINE |
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