Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: a sham-controlled study.

Autor: Rodionov A; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Ozdemir RA; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Benwell CSY; Division of Psychology, School of Humanities, Social Sciences and Law, University of Dundee, Dundee, UK., Fried PJ; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Boucher P; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Momi D; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Canada., Ross JM; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Research, Education, and Clinical Center, Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Palo Alto, CA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Stanford, CA, USA., Santarnecchi E; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Precision Neuroscience and Neuromodulation Program, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Pascual-Leone A; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Deanna and Sidney Wolk Center for Memory Health, Hebrew Senior Life, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, USA., Shafi MM; Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA. mshafi@bidmc.harvard.edu.; Department of Neurology, Harvard Medical School, Boston, MA, USA. mshafi@bidmc.harvard.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 02; Vol. 13 (1), pp. 18898. Date of Electronic Publication: 2023 Nov 02.
DOI: 10.1038/s41598-023-45512-6
Abstrakt: Theta burst stimulation (TBS) is a form of repetitive transcranial magnetic stimulation designed to induce changes of cortical excitability that outlast the period of TBS application. In this study, we explored the effects of continuous TBS (cTBS) and intermittent TBS (iTBS) versus sham TBS stimulation, applied to the left primary motor cortex, on modulation of resting state electroencephalography (rsEEG) power. We first conducted hypothesis-driven region-of-interest (ROI) analyses examining changes in alpha (8-12 Hz) and beta (13-21 Hz) bands over the left and right motor cortex. Additionally, we performed data-driven whole-brain analyses across a wide range of frequencies (1-50 Hz) and all electrodes. Finally, we assessed the reliability of TBS effects across two sessions approximately 1 month apart. None of the protocols produced significant group-level effects in the ROI. Whole-brain analysis revealed that cTBS significantly enhanced relative power between 19 and 43 Hz over multiple sites in both hemispheres. However, these results were not reliable across visits. There were no significant differences between EEG modulation by active and sham TBS protocols. Between-visit reliability of TBS-induced neuromodulatory effects was generally low-to-moderate. We discuss confounding factors and potential approaches for improving the reliability of TBS-induced rsEEG modulation.
(© 2023. The Author(s).)
Databáze: MEDLINE
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