Advances in Etiopathological Role and Control of HPV in Cervical Cancer Oncogenesis.

Autor:	Kombe AJK; Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China., Zoa-Assoumou S; Departement de Bacteriologie-Virologie, Université des Sciences de la Santé, BP 18231 Libreville, Gabon., Bounda GA; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 210009 Jiangsu, Nanjing, China., Nsole-Biteghe FA; Department of Radiation Oncology, Cedars Sinai Hospital, Los Angeles, CA 90048, USA., Jin T; Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, Anhui, China.; Institute of Health and Medicine, Hefei Comprehensive National Science Center, 230007 Hefei, Anhui, China., Zouré AA; Institut de Recherche en Science de la Santé, Centre National de Recherche Scientifique et Technologique (IRSS/CNRST), BP 7047 Ouagadougou 03, Burkina Faso.
Jazyk:	angličtina
Zdroj:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2023 Oct 19; Vol. 28 (10), pp. 245.
DOI:	10.31083/j.fbl2810245
Abstrakt:	The human papillomavirus (HPV) is a well-known oncovirus whose causal link in the occurrence and development of several cancers, such as cervical cancer (CC), has been well established. Indeed, numerous researches depicted the etiological role of HPV in CC pathogenesis in such a way as to develop efficient strategies, including early diagnoses and HPV vaccination, to mitigate HPV infection and CC occurrence. Despite the effectiveness of these strategies in preventing HPV infection, its persistence, and the progression to precancerous lesions and cancers, extensive work that could give a better understanding of other unknown factors favoring oncogenesis is much more needed. In this last decade, scarce or few but crucial and strategic studies have been carried out to improve and deepen our understanding of the etiopathological role of HPV in the progression towards the development of CC. In this review, we highlighted the recent findings on the pathological role of HPV in CC occurrence and the advances in novel adopted strategies to reduce HPV infection and prevent CC occurrence more effectively. Competing Interests: The authors declare no conflict of interest. (© 2023 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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