Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs.

Autor:	Thomas SC; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Miller G; Cancer Center, Holy Name Medical Center, Teaneck, NJ, USA., Li X; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.; Perlmutter Cancer Institute, New York University Langone Medical Center, New York, NY, USA.; Department of Urology, New York University Grossman School of Medicine, New York, NY, USA., Saxena D; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA ds100@nyu.edu.; Perlmutter Cancer Institute, New York University Langone Medical Center, New York, NY, USA.; Department of Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Gut [Gut] 2023 Dec 07; Vol. 73 (1), pp. 175-185. Date of Electronic Publication: 2023 Dec 07.
DOI:	10.1136/gutjnl-2022-328834
Abstrakt:	The gastrointestinal ecosystem has received the most attention when examining the contributions of the human microbiome to health and disease. This concentration of effort is logical due to the overwhelming abundance of microbes in the gut coupled with the relative ease of sampling compared with other organs. However, the intestines are intimately connected to multiple extraintestinal organs, providing an opportunity for homeostatic microbial colonisation and pathogenesis in organs traditionally thought to be sterile or only transiently harbouring microbiota. These habitats are challenging to sample, and their low microbial biomass among large amounts of host tissue can make study challenging. Nevertheless, recent findings have shown that many extraintestinal organs that are intimately linked to the gut harbour stable microbiomes, which are colonised from the gut in selective manners and have highlighted not just the influence of the bacteriome but that of the mycobiome and virome on oncogenesis and health. Competing Interests: Competing interests: XL and DS are cofounders of Periomicscare. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu