Comparison of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) as marker of adverse prognosis in patients with infective endocarditis.

Autor:	Thottuvelil SR; Consultant Interventional Cardiologist, Department of Cardiology, Aster Medcity, Kochi, Kerala, 682027, India. Electronic address: drsunil.roy@asterhospital.com., Chacko M; Clinical Research Analyst, Department of Clinical Research, Aster Medcity, Kochi, Kerala, 682027, India., Warrier AR; Consultant Infectious Disease, Department of Infectious Disease, Aster Medcity, Kochi, Kerala, 682027, India., Nair MP; Consultant Cardiac Surgeon, Department of Cardiovascular Surgery, Aster Medcity, Kochi, Kerala, 682027, India., Rajappan AK; Lead Consultant Interventional Cardiologist, Department of Cardiology, Aster Medcity, Kochi, Kerala, 682027, India.
Jazyk:	angličtina
Zdroj:	Indian heart journal [Indian Heart J] 2023 Nov-Dec; Vol. 75 (6), pp. 465-468. Date of Electronic Publication: 2023 Nov 02.
DOI:	10.1016/j.ihj.2023.10.008
Abstrakt:	Infective Endocarditis (IE) remains a life-threatening condition and early risk stratification helps us to predict mortality and the need for aggressive treatment. We compared NLR, PLR, and SII, on admission to predict in-hospital mortality. Consecutive IE patients, who met inclusion criteria were analysed. Receiver operating characteristic curve (ROC) analysis was conducted for NLR, PLR, and SII to predict in-hospital mortality. The median value of NLR was 19.6 (10.1-27) in patients with mortality, and 5.4 (3.2-8.5) in alive patients. The median value of PLR and SII were comparable in both groups. The area under the ROC curve of NLR showed a significant value of 0.83 (p = 0.001). A Kaplan Meier survival analysis for patients taking a cut-off value of NLR (9.8) was statistically significant (p < 0.001). In multivariate regression model, only NLR was statistically significant predictor of mortality. So NLR, which is a simple, readily available, and inexpensive parameter has a better association with in-hospital mortality in IE patients. Competing Interests: Declaration of competing interest All authors confirm that they have nothing to declare. (Copyright © 2023 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.)
Databáze:	MEDLINE
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