Nano-injectable pH/NIR-responsive hydrogel for chemo-photothermal synergistic drug delivery.

Autor:	Zhao Q; Key Laboratory of Functional Polymer Materials of MOE, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China., Yue X; Key Laboratory of Functional Polymer Materials of MOE, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China., Miaomiao L; College of Pharmacy, Nankai University, Tianjin, China., Yanming W; College of Pharmacy, Nankai University, Tianjin, China., Wu G; Key Laboratory of Functional Polymer Materials of MOE, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Jazyk:	angličtina
Zdroj:	Journal of biomaterials applications [J Biomater Appl] 2023 Nov; Vol. 38 (5), pp. 614-628. Date of Electronic Publication: 2023 Nov 02.
DOI:	10.1177/08853282231209653
Abstrakt:	Conventional cancer treatments are highly toxic and ineffective; therefore, it is essential to develop less toxic and minimally invasive treatment methods. A pH/Near Infra-red (NIR) dual-responsive, nano-injectable smart hydrogel was fabricated by incorporating CuS nanoparticles into the hydrogel networks formed by a random copolymer of N-isopropylacrylamide (NIPAM) and double-bond functionalized uracil. Microstructural characterizations of synthesized polymer and hydrogels were carried out using transmission electron microscope (TEM), scanning electron microscope (SEM), nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FT-IR). Multiple hydrogen bonding interactions between uracils function as physical cross-linking points to construct the network structure of the polymeric nanogel without the addition of additional cross-linking agents, ensuring the material's safety. The amino group on the structure of uracil gives the uracil-modified polymeric hydrogel excellent pH responsiveness. Notably, as a temperature-responsive material, poly (N-isopropylacrylamide) (PNIPAM) nanogel solution can achieve in situ gel formation (within 100 s at 37°C) above its lower critical solution temperature (LCST), granting injectability to polymeric solutions. Moreover, using a hierarchical construction strategy, the variable loading of DOX and CuS was achieved. First, a heterogeneous system was created by encapsulating doxorubicin (DOX) inside the nanogel via hydrophobic and π-π stacking interactions, followed by the introduction of CuS nanoparticles as photosensitizers outside of the nanogels. Due to the presence of CuS nanoparticles, the gel is able to convert NIR light into local heat to enhance the destruction of tumor cells while simultaneously achieving rapid in situ gel formation. The in situ-forming hydrogel showed promising tissue biocompatibility. The in vitro antitumor test demonstrated the capacity of the nanocomposite hydrogel for chemo-photothermal synergistic therapy. Therefore, this prepared platform has the potential to become a safe and effective, smart-responsive drug carrier for chemotherapy and PTT synergy, a minimally invasive material for tumor treatment. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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