Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure.

Autor: De Gasperi R; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gama Sosa MA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; General Medical Research Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Perez Garcia G; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Perez GM; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Pryor D; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Morrison CL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Northeast Regional Alliance Health Careers Opportunity Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lind R; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA., Abutarboush R; Department of Neurotrauma, Naval Medical Research Command, Silver Spring, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, Maryland, USA., Kawoos U; Department of Neurotrauma, Naval Medical Research Command, Silver Spring, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, Maryland, USA., Statz JK; Department of Neurotrauma, Naval Medical Research Command, Silver Spring, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, Maryland, USA., Patterson J; Department of Neurotrauma, Naval Medical Research Command, Silver Spring, Maryland, USA., Hof PR; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Zhu CW; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Geriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Ahlers ST; Department of Neurotrauma, Naval Medical Research Command, Silver Spring, Maryland, USA., Cook DG; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Pharmacology, and Psychiatry, University of Washington, Seattle, Washington, USA.; Department of Behavioral Sciences, University of Washington, Seattle, Washington, USA., Elder GA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Neurology Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA.
Jazyk: angličtina
Zdroj: Journal of neurotrauma [J Neurotrauma] 2024 Mar; Vol. 41 (5-6), pp. 714-733. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1089/neu.2023.0252
Abstrakt: Many military veterans who experienced blast-related traumatic brain injuries in the conflicts in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop cognitive and PTSD-related behavioral traits that are present for more than 1 year after exposure. We previously reported that a group II metabotropic receptor (mGluR2/3) antagonist reversed blast-induced behavioral traits. In this report, we explored mGluR2/3 expression following blast exposure in male rats. Western blotting revealed that mGluR2 protein (but not mGluR3) was increased in all brain regions studied (anterior cortex, hippocampus, and amygdala) at 43 or 52 weeks after blast exposure but not at 2 weeks or 6 weeks. mGluR2 RNA was elevated at 52 weeks while mGluR3 was not. Immunohistochemical staining revealed no changes in the principally presynaptic localization of mGluR2 by blast exposure. Administering the mGluR2/3 antagonist LY341495 after behavioral traits had emerged rapidly reversed blast-induced effects on novel object recognition and cued fear responses 10 months following blast exposure. These studies support alterations in mGluR2 receptors as a key pathophysiological event following blast exposure and provide further support for group II metabotropic receptors as therapeutic targets in the neurobehavioral effects that follow blast injury.
Databáze: MEDLINE