Human lower leg muscles grow asynchronously.

Autor: Chow BVY; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Morgan C; Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia., Rae C; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Warton DI; School of Mathematics and Statistics, University of New South Wales, Sydney, New South Wales, Australia.; Evolution & Ecology Research Centre, University of New South Wales, Sydney, New South Wales, Australia., Novak I; Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Davies S; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia., Lancaster A; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia., Popovic GC; Stats Central, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, New South Wales, Australia., Rizzo RRN; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Rizzo CY; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia., Kyriagis M; Rehab2Kids, Sydney Children's Hospital, Sydney, New South Wales, Australia., Herbert RD; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Bolsterlee B; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Journal of anatomy [J Anat] 2024 Mar; Vol. 244 (3), pp. 476-485. Date of Electronic Publication: 2023 Nov 02.
DOI: 10.1111/joa.13967
Abstrakt: Muscle volume must increase substantially during childhood growth to generate the power required to propel the growing body. One unresolved but fundamental question about childhood muscle growth is whether muscles grow at equal rates; that is, if muscles grow in synchrony with each other. In this study, we used magnetic resonance imaging (MRI) and advances in artificial intelligence methods (deep learning) for medical image segmentation to investigate whether human lower leg muscles grow in synchrony. Muscle volumes were measured in 10 lower leg muscles in 208 typically developing children (eight infants aged less than 3 months and 200 children aged 5 to 15 years). We tested the hypothesis that human lower leg muscles grow synchronously by investigating whether the volume of individual lower leg muscles, expressed as a proportion of total lower leg muscle volume, remains constant with age. There were substantial age-related changes in the relative volume of most muscles in both boys and girls (p < 0.001). This was most evident between birth and five years of age but was still evident after five years. The medial gastrocnemius and soleus muscles, the largest muscles in infancy, grew faster than other muscles in the first five years. The findings demonstrate that muscles in the human lower leg grow asynchronously. This finding may assist early detection of atypical growth and allow targeted muscle-specific interventions to improve the quality of life, particularly for children with neuromotor conditions such as cerebral palsy.
(© 2023 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.)
Databáze: MEDLINE
Externí odkaz: