| Autor: |
Ginsberg J, Walfish PG, Rafter DJ, von Westarp C, Ehrlich RM |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical endocrinology [Clin Endocrinol (Oxf)] 1986 Aug; Vol. 25 (2), pp. 189-94. |
| DOI: |
10.1111/j.1365-2265.1986.tb01681.x |
| Abstrakt: |
We examined IgG from 15 mothers of infants with congenital hypothyroidism for their ability to block TSH-stimulated iodine organification in vitro. Only one out of 15 of these IgGs exhibited TSH-blocking activity. This IgG could inhibit TSH action by 30-50%. It could not block radiolabelled TSH from binding to its receptor but did inhibit dibutyryl cyclic AMP stimulation of iodine organification implying a unique effect on post-receptor processes via a membrane binding site distant from the TSH binding site. Interestingly there was no evidence of autoimmune thyroid disease in the mother. These results suggest that the transplacental passage of TSH-blocking antibodies plays little, if any, role in the development of congenital hypothyroidism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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