Prognostic value of 18 F-FDG PET in uterine cervical cancer patients with stage IIICr allocated by imaging.

Autor: Isaji Y; Department of Obstetrics and Gynecology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan., Tsuyoshi H; Department of Obstetrics and Gynecology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. go242h@yahoo.co.jp., Tsujikawa T; Department of Radiology, University of Fukui, Fukui, Japan., Orisaka M; Department of Obstetrics and Gynecology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan., Okazawa H; Biomedical Imaging Research Center, University of Fukui, Fukui, Japan., Yoshida Y; Department of Obstetrics and Gynecology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 01; Vol. 13 (1), pp. 18864. Date of Electronic Publication: 2023 Nov 01.
DOI: 10.1038/s41598-023-46261-2
Abstrakt: The effect on survival of radiographic lymph node metastasis in uterine cervical cancer patients is more important than before, even though its prognostic value not been well investigated. The aim of our study is to evaluate the prognostic potential of 18 F-fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET) compared with Computed Tomography (CT) in uterine cervical cancer patients with stage IIICr allocated by imaging. Fifty-five patients with biopsy-proven primary cervical cancer underwent definitive radiation therapy for stages IIB-IVB of The International Federation of Gynecology and Obstetrics (FIGO) 2018 classifications. The prognostic performance of pretreatment 18 F-FDG PET and CT for assessing lymph node metastasis was evaluated by two experienced readers. The PET and CT findings were correlated with the risk of progression-free survival (PFS) and overall survival (OS). Kaplan-Meier survival curves showed that PFS was significantly worse in patients with positive lymph nodes on 18 F-FDG PET than in those patients with negative lymph nodes on 18 F-FDG PET (p = 0.003), whereas there was no significant difference in PFS between patients with lymph nodes sized ≥ 1 cm and those sized < 1 cm (p = 0.140). Univariate analysis showed that positive lymph nodes on 18 F-FDG PET was significantly associated with poor PFS (p = 0.006), whereas lymph node size was not significantly associated with poor PFS (p = 0.145). In multivariate analysis, positive lymph nodes on 18 F-FDG PET was significantly associated with poor PFS (p = 0.006) and was an independent prognostic factor for PFS. 18 F-FDG PET offers high prognostic value for patients with stage IIICr allocated by imaging compared with CT, suggesting that 18 F-FDG PET might be useful in clinical staging decisions and thus promote optimal diagnostic and therapeutic strategies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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