Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study.

Autor: Soloukey S; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Collée E; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Verhoef L; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands., Satoer DD; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Dirven CMF; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Bos EM; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Schouten JW; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Generowicz BS; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands., Mastik F; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands., De Zeeuw CI; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands; Netherlands Institute for Neuroscience, Royal Dutch Academy for Arts and Sciences, Amsterdam 1105 BA, the Netherlands., Koekkoek SKE; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands., Vincent AJPE; Department of Neurosurgery, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Smits M; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam 3015 CN, the Netherlands., Kruizinga P; Department of Neuroscience, Erasmus MC, Wytemaweg 80 3015 CN, Rotterdam 3015 CN, the Netherlands. Electronic address: p.kruizinga@erasmusmc.nl.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2023 Dec 01; Vol. 283, pp. 120435. Date of Electronic Publication: 2023 Oct 30.
DOI: 10.1016/j.neuroimage.2023.120435
Abstrakt: Accurate, depth-resolved functional imaging is key in both understanding and treatment of the human brain. A new sonography-based imaging technique named functional Ultrasound (fUS) uniquely combines high sensitivity with submillimeter-subsecond spatiotemporal resolution available in large fields-of-view. In this proof-of-concept study we show that: (A) fUS reveals the same eloquent regions as found by fMRI while concomitantly visualizing in-vivo microvascular morphology underlying these functional hemodynamics and (B) fUS-based functional maps are confirmed by Electrocortical Stimulation Mapping (ESM), the current gold-standard in awake neurosurgical practice. This unique cross-modality experiment was performed using motor, visual and language-related functional tasks in patients undergoing awake brain tumor resection. The current work serves as an important milestone towards further maturity of fUS as well as a novel avenue to increase our understanding of hemodynamics-based functional brain imaging.
Competing Interests: Declaration of Competing Interest The authors have no relevant competing interests to declare.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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