Ameloblastic fibro-odontosarcoma with mandibular bone invasion and regional lymph node metastasis in a cat: case report.
Autor: | Nordio L; Pathology Division, San Marco Veterinary Clinic and Laboratory, Via dell'Industria 3, 35030 Veggiano, Padua, Italy. Electronic address: laura.nordio@sanmarcovet.it., Costa A; Diagnostic and Interventional Radiology Division, San Marco Veterinary Clinic and Laboratory, Via dell'Industria 3, 35030 Veggiano, Padua, Italy., Campigli M; Oncology Division, San Marco Veterinary Clinic and Laboratory, Via dell'Industria 3, 35030 Veggiano, Padua, Italy., Rondena M; Pathology Division, San Marco Veterinary Clinic and Laboratory, Via dell'Industria 3, 35030 Veggiano, Padua, Italy. |
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Jazyk: | angličtina |
Zdroj: | Journal of comparative pathology [J Comp Pathol] 2023 Nov; Vol. 207, pp. 18-20. Date of Electronic Publication: 2023 Oct 30. |
DOI: | 10.1016/j.jcpa.2023.09.008 |
Abstrakt: | Odontogenic tumours are uncommon neoplasms in domestic animals, mostly solitary and locally infiltrative, but rarely metastatic. We report the case of a 13-year-old neutered male cat presented with a mandibular gingival neoformation. A computed tomography scan revealed an irregular neoformation with marked post-contrast enhancement, associated with lysis of the incisive bone and mandibular symphysis. Histologically, the oral mucosa and mandibular bone were infiltrated by a neoplasm consisting of a mixed population of odontogenic epithelium admixed with bundles of odontogenic ectomesenchyme, multifocally associated with hard tissue deposition. A spindloid cell component had metastasized to the right mandibular lymph node. The epithelial component was immunoreactive for cytokeratins (CK) 5/6, CK 14, pancytokeratin (CK AE1/AE3) and p63; the ectomesenchymal component was vimentin positive. A final diagnosis of ameloblastic fibro-odontosarcoma with bone invasion and lymph node metastasis was made. The findings indicate the metastatic potential of this rare tumour. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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