Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.

Autor:	Phiri TN; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Mutasa K; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Rukobo S; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Govha M; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Mushayanembwa P; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Mwakamui S; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Haider T; Blizard Institute, Queen Mary University of London, London, UK., Zyambo K; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Dumbura C; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Tome J; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Runodamoto T; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Chidamba L; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Majo FD; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Ngosa D; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Chandwe K; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Kapoma C; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Mwapenya B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Mufukari W; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Sturgeon JP; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.; Blizard Institute, Queen Mary University of London, London, UK., Robertson RC; Blizard Institute, Queen Mary University of London, London, UK., Smuk M; Blizard Institute, Queen Mary University of London, London, UK., Ntozini R; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Nathoo K; Department of Paediatrics and Child Health, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Amadi B; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia., Kelly P; Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia.; Blizard Institute, Queen Mary University of London, London, UK., Bwakura-Dangarembizi M; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.; Department of Paediatrics and Child Health, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Prendergast AJ; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.; Blizard Institute, Queen Mary University of London, London, UK., Bourke CD; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.; Blizard Institute, Queen Mary University of London, London, UK.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2023 Nov 03; Vol. 9 (44), pp. eadh2284. Date of Electronic Publication: 2023 Nov 01.
DOI:	10.1126/sciadv.adh2284
Abstrakt:	Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe ( n = 141) have distinct capacity to respond to bacteria relative to adequately nourished healthy controls ( n = 92). SAM inpatients had higher neutrophil and monocyte Escherichia coli binding capacity but lower monocyte activation and proinflammatory mediator secretion in response to lipopolysaccharide or heat-killed Salmonella typhimurium than controls. Among SAM cases, wasting severity was negatively associated with cytokine secretion, children with HIV had lower monocyte activation, and the youngest children released the least myeloperoxidase upon stimulation. Inpatient bacterial binding capacity and monocyte activation were associated with higher odds of persistent SAM at discharge, a risk factor for subsequent mortality. Thus, SAM shifts innate immune cell function, favoring bacterial containment over proinflammatory activation, which may contribute to health deficits after discharge.
Databáze:	MEDLINE
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