Comparison of the effect of hyperbaric oxygen therapy and tadalafil daily use on erectile function: a prospective, double controlled study.

Autor: Eker A; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey. anileker993@gmail.com., Celik S; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Ozer EE; Department of Hyperbaric Medicine, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Basmacı I; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Sefik E; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Bozkurt IH; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Gunlusoy B; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey., Degirmenci T; Department of Urology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, Izmir, Turkey.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2024 Mar; Vol. 56 (3), pp. 867-876. Date of Electronic Publication: 2023 Nov 01.
DOI: 10.1007/s11255-023-03852-2
Abstrakt: Purpose: Erectile dysfunction (ED) is a worldwide health problem. Oral phosphodiesterase type 5 inhibitors (PDE5I) are used in its first-line treatment. This study aimed to compare the effects of hyperbaric oxygen (HBO) treatment with PDE5I treatment and determine the patient-dependent factors affecting the efficacy of the HBO treatment and duration of action of HBO treatment.
Methods: Adult male patients who presented to the HBO unit for HBO treatment with non-urological indications and had ED based on the International Index for Erectile Function (IIEF-5) constituted the target population of this study. Participants were given HBO treatment (Group 1), no treatment (Group 2), or daily oral tadalafil 5 mg treatment (Group 3). The treatment duration was 1 month. Patients were assessed by IIEF-5 both initially and after the completion of 1 month.
Results: There were significant increases in the mean IIEF-5 scores of the patients in Group 1 and Group 3 (p < 0.001, p < 0.001). However, there was no significant improvement in Group 2 (p = 0.496). Also, the post-treatment IIEF-5 scores of Group 1 and Group 3 were significantly higher than Group 2 (p < 0.001). There was no significant difference between the IIEF-5 scores and ∆IIEF-5 values of Group 1 and Group 3 (p = 0.166, p = 0.093). Evaluation regarding comorbidities revealed that patients with the peripheral vascular disease did not improve with HBO treatment (p = 0.285).
Conclusion: HBO can improve erectile functions, and it can be a reasonable alternative for patients who cannot use PDE5Is due to comorbidities or treatment side effects.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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