Effect of ethanolic extracts from Piperaceae leaves on the reduction of skin necrosis and wound healing in an animal model of degloving injuries.

Autor:	Menon DN; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil.; Universidade Federal da Grande Dourados - General Surgery - Dourados (MS) - Brazil., Leite IAB; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Ramsdorf MTA; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Chagas LDS; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Arroyo SA; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Santos ACD; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Kassuya CAL; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil., Mota JDS; Universidade Estadual de Mato Grosso do Sul - Chemistry Department - Dourados (MS) - Brazil., Barros ME; Universidade Federal da Grande Dourados - Health Science Department - Dourados (MS) - Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2023 Oct 30; Vol. 38, pp. e387223. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023).
DOI:	10.1590/acb387223
Abstrakt:	Purpose: To assess the effect of the ethanolic extract of the leaves of three species of plants from the Piperaceae family on reducing necrosis and enhancing wound healing in an animal model of degloving injuries. Methods: The animals were divided into six groups, each consisting of six animals: sham, negative control, EEPA (Piper amalago ethanolic extract), EEPG (Piper glabratum ethanolic extract), EEPV (Piper vicosanum ethanolic extract), and positive control receiving hyperbaric oxygenation. The animals underwent surgery to induce excision wounds, and the extent of cutaneous necrosis was evaluated using graphic software, while wound healing was assessed through histopathology. Results: Skin necrosis percentage area was: sham group = 62.84% 6.38; negative control group = 63.03% 4.11; P. vicosanum = 40.80% 4.76 p < 0.05; P. glabratum 32.97% 4.01 p < 0.01; P. amalago = 32.40% 4.61 p < 0.01; hyperbaric oxygenation = 33.21% 4.29 p < 0.01. All treated groups showed higher collagen deposition and less intense, plus predominantly mononuclear inflammatory infiltrate, suggesting improved healing process. Conclusions: The three tested extracts demonstrated efficacy in reducing the extent of cutaneous necrosis caused by degloving injuries and also showed evidence of improvement in the wound healing process.
Databáze:	MEDLINE
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