Nuclear mechanosensing of the aortic endothelium in health and disease.
| Autor: | Mannion AJ; Department of Oncology-Pathology, Karolinska Institute, Stockholm 171 64, Sweden., Holmgren L; Department of Oncology-Pathology, Karolinska Institute, Stockholm 171 64, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Disease models & mechanisms [Dis Model Mech] 2023 Oct 01; Vol. 16 (10). Date of Electronic Publication: 2023 Nov 01. |
| DOI: | 10.1242/dmm.050361 |
| Abstrakt: | The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a number of mechanical forces, including frictional shear flow, pulsatile stretching and changes in stiffness influenced by extracellular matrix composition. These forces are sensed by mechanosensors that facilitate their transduction to drive appropriate adaptation of the endothelium to maintain vascular homeostasis. In the aorta, the unique architecture of the vessel gives rise to changes in the fluid dynamics, which, in turn, shape cellular morphology, nuclear architecture, chromatin dynamics and gene regulation. In this Review, we discuss recent work focusing on how differential mechanical forces exerted on endothelial cells are sensed and transduced to influence their form and function in giving rise to spatial variation to the endothelium of the aorta. We will also discuss recent developments in understanding how nuclear mechanosensing is implicated in diseases of the aorta. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2023. Published by The Company of Biologists Ltd.) |
| Databáze: | MEDLINE |
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