Follicular adenoma with bizarre nuclei and wild-type P53 expression: A case report and literature review.

Autor: Nguyen D; Department of Pathology and Laboratory Medicine, University of California at Irvine Health System, Orange, CA, USA., Htun NN; Department of Pathology and Laboratory Medicine, University of California at Irvine Health System, Orange, CA, USA., Wang B; Department of Pathology and Laboratory Medicine, University of California at Irvine Health System, Orange, CA, USA.
Jazyk: angličtina
Zdroj: Rare tumors [Rare Tumors] 2023 Oct 28; Vol. 15, pp. 20363613231212383. Date of Electronic Publication: 2023 Oct 28 (Print Publication: 2023).
DOI: 10.1177/20363613231212383
Abstrakt: Introduction: Thyroid cancer is the most common endocrine tumor in humans. Follicular adenoma/carcinoma is the second most common subtype. Multiple histological patterns have been identified. Follicular adenoma with bizarre nuclei is one of the patterns associated with p53 mutation and has an unclear clinical prognosis.
Case Report: A 74-year-old female presented with incidental findings of elevated TSH levels and normal thyroid markers. Ultrasound was performed and revealed multiple bilateral thyroid nodules measuring up to 1.9 cm. Fine needle aspiration was performed, and cytology showed one Bethesda category 5 nodule. Total thyroidectomy with neck dissection was performed, and the pathology showed follicular adenoma with bizarre nuclei. Based on the results of immunohistochemistry, the neoplastic cells exhibited staining for wild-type p53 and low levels of the proliferation index Ki-67.
Conclusions: We report a rare case of thyroid follicular adenoma with bizarre nuclei. In contrast to previous reports of this tumor, our patient showed a p53 wild-type pattern using immunohistochemistry. More studies are needed to better understand the etiology and clinical prognosis of this tumor.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2023.)
Databáze: MEDLINE
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