Revolutionizing Heart Transplantation: A Multidisciplinary Approach to Xenotransplantation, Immunosuppression, Regenerative Medicine, Artificial Intelligence, and Economic Sustainability.

Autor:	Tanveer Y; Urology, Craigavon Area Hospital, Craigavon, GBR., Arif A; Internal Medicine, Allama Iqbal Medical College, Lahore, PAK., Tsenteradze T; General Surgery, Cardiology, and Internal Medicine, Tbilisi State Medical University, Tbilisi, GEO., Anika NN; Surgery, Baylor College of Medicine, Houston, USA.; Internal Medicine, Holy Family Red Crescent Medical College and Hospital, Dhaka, BGD., Bakht D; Medicine and Surgery, Mayo Hospital, Lahore, PAK., Masood QF; Surgery, National University of Science and Technology, Rawalpindi, PAK., Affaf M; Internal Medicine, Women Medical and Dental College, Abbottabad, PAK., Batool W; Internal Medicine, Army Medical College, Rawalpindi, PAK., Yadav I; Internal Medicine, Samar Hospital and Research Center Pvt. Ltd., Janakpur, NPL.; Internal Medicine, Community Based Medical College Bangladesh, Mymensingh, BGD., Gasim RW; Internal Medicine, University of Khartoum, Khartoum, SDN., Mohamed Y; Intensive Care Unit, Ibrahim Malik Teaching Hospital, Khartoum, SDN., Abdelmonim Khogali Mohamed M; Cardiac Critical Care, King Abdulaziz Medical City, Riyadh, SAU., Ekhator C; Neuro-Oncology, New York Institute of Technology, College of Osteopathic Medicine, New York, USA., Mohsin SN; Orthopedics, St. James's Hospital, Dublin, IRL.; General Surgery, Cavan General Hospital, Cavan, IRL., Khan R; Internal Medicine, Mayo Hospital, Lahore, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Sep 29; Vol. 15 (9), pp. e46176. Date of Electronic Publication: 2023 Sep 29 (Print Publication: 2023).
DOI:	10.7759/cureus.46176
Abstrakt:	Heart transplantation (HTx) stands as a life-saving intervention for patients with end-stage heart disease, but the field is fraught with numerous challenges that span from the scarcity of donor organs to long-term complications arising from immunosuppressive therapies. This comprehensive review article offers an in-depth exploration of the multifaceted aspects of HTx. The review covers groundbreaking advancements in xenotransplantation, enabled by cutting-edge genetic engineering techniques, and the promising role of stem cell therapies, particularly porcine mesenchymal stem cells, in cardiac regeneration. It also delves into the evolution and limitations of immunosuppressive therapies and the revolutionary potential of artificial intelligence (AI) and machine learning (ML) in enhancing donor-recipient matching and predicting patient outcomes. Economic considerations, especially in the context of rising healthcare costs, are examined to assess the sustainability of these advancements. The article further discusses the significant improvements in patient outcomes over the years, while highlighting persisting challenges, such as graft failure, rejection, and infection. It underscores the importance of experience and specialized training, evidenced by the presence of an institutional learning curve. The review concludes by advocating for a multifaceted, collaborative approach involving clinicians, researchers, and policymakers to overcome existing challenges. Through coordinated efforts that consider medical, ethical, and economic factors, the field of HTx is poised for further evolution, offering renewed hope for improved patient care and outcomes. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Tanveer et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu