Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa.

Autor:	Baldeh M; Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Bawa FK; West African Center for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana., Bawah FU; Department of Computer Science, University of Ghana, Accra, Ghana.; Department of Computer Science and Informatics, University of Energy and Natural Resources, Sunyani, Ghana., Chamai M; West African Center for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana., Dzabeng F; West African Center for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.; Department of Computer Science, University of Ghana, Accra, Ghana., Jebreel WMA; Institute of Endemic-Diseases, University of Khartoum, Khartoum, Sudan., Kabuya JB; Tropical Diseases Research Centre, Ndola, Zambia., Molemodile Dele-Olowu SK; School of Public Health, University of Ghana, Accra, Ghana., Odoyo E; Masinde Muliro University of Science & Technology, Kakamega, Kenya., Rakotomalala Robinson D; Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Cunnington AJ; Section of Paediatric Infectious Disease and Centre for Paediatrics and Child Health, Imperial College, London, UK.
Jazyk:	angličtina
Zdroj:	Expert review of molecular diagnostics [Expert Rev Mol Diagn] 2024 Mar; Vol. 24 (3), pp. 153-159. Date of Electronic Publication: 2023 Nov 09.
DOI:	10.1080/14737159.2023.2277368
Abstrakt:	Introduction: Point-of-care molecular diagnostics offer solutions to the limited diagnostic availability and accessibility in resource-limited settings. During the COVID-19 pandemic, molecular diagnostics became essential tools for accurate detection and monitoring of SARS-CoV-2. The unprecedented demand for molecular diagnostics presented challenges and catalyzed innovations which may provide lessons for the future selection of point-of-care molecular diagnostics. Areas Covered: We searched PubMed from January 2020 to August 2023 to identify lessons learned from the COVID-19 pandemic which may impact the selection of point-of-care molecular diagnostics for future use in sub-Saharan Africa. We evaluated this in the context of REASSURED criteria (Real-time connectivity; Ease of specimen collection; Affordable; Sensitive; Specific; User-friendly; Rapid and robust; Equipment free; and Deliverable to users at the point of need) for point-of-care diagnostics for resource-limited settings. Expert Opinion: The diagnostic challenges and successes during the COVID-19 pandemic affirmed the importance of the REASSURED criteria but demonstrated that these are not sufficient to ensure new diagnostics will be appropriate for public health emergencies. Capacity for rapid scale-up of diagnostic testing and transferability of assays, data, and technology are also important, resulting in updated REST-ASSURED criteria. Few diagnostics will meet all criteria, and trade-offs between criteria will need to be context-specific.
Databáze:	MEDLINE
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