Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance.

Autor:	Xue CY; Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China., Gao T; Division of Health Management, Tangdu Hospital, Fourth Military Medical University, Xi'an, China., Mao E; Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an, China., Kou ZZ; Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an, China., Dong L; Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China., Gao F; Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China.
Jazyk:	angličtina
Zdroj:	ASN neuro [ASN Neuro] 2023 Jan-Dec; Vol. 15, pp. 17590914231206657.
DOI:	10.1177/17590914231206657
Abstrakt:	It is well known that the hippocampus is a vital brain region playing a key role in both episodic and spatial memory. Insulin receptors (InsRs) are densely distributed in the hippocampus and are important for its function. However, the effects of InsRs on the function of the specific hippocampal cell types remain elusive. In this study, hippocampal InsRs knockout mice had impaired episodic and spatial memory. GABAergic neurons and glutamatergic neurons in the hippocampus are involved in the balance between excitatory and inhibitory (E/I) states and participate in the processes of episodic and spatial memory. InsRs are located mainly at excitatory neurons in the hippocampus, whereas 8.5% of InsRs are glutamic acid decarboxylase 2 (GAD2)::Ai9-positive (GABAergic) neurons. Next, we constructed a transgenic mouse system in which InsR expression was deleted from GABAergic (glutamate decarboxylase 2::InsR fl/fl , GAD2 Cre ::InsR fl/fl ) or glutamatergic neurons (vesicular glutamate transporter 2::InsR fl/fl ,Vglut2 Cre ::InsR fl/fl ). Our results showed that in comparison to the InsR fl/fl mice, both episodic and spatial memory were lower in GAD2 Cre ::InsR fl/fl and Vglut2 Cre ::InsR fl/fl . In addition, both GAD2 Cre ::InsR fl/fl and Vglut2 Cre ::InsR fl/fl were associated with more anxiety and lower glucose tolerance. These findings reveal that hippocampal InsRs might be crucial for episodic and spatial memory through E/I balance hippocampal regulation. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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