Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis).

Autor: Schwartz K; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Zhang M; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Franco B; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Jampachaisri K; Department of Mathematics, Naresuan University, Phitsanulok, Thailand., Cotton RM; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Huss MK; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Fisher KM; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Darian-Smith C; Department of Comparative Medicine, Stanford University, Stanford, California, USA., Sharp P; University of California, Merced, California, USA.; Murdoch University, Murdoch, Western Australia, Australia., Pablo L; Department of Comparative, Diagnostic & Population Medicine, University of Florida College, Gainesville, Florida, USA., Pacharinsak C; Department of Comparative Medicine, Stanford University, Stanford, California, USA.
Jazyk: angličtina
Zdroj: Journal of medical primatology [J Med Primatol] 2024 Feb; Vol. 53 (1), pp. e12682. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1111/jmp.12682
Abstrakt: Background: Atipamezole, an α-2 adrenergic receptor antagonist, reverses the α-2 agonist anesthetic effects. There is a dearth of information on the physiological effects of these drugs in cynomolgus macaques (Macaca fascicularis). We assessed atipamezole's physiologic effects. We hypothesized atipamezole administration would alter anesthetic parameters.
Methods: Five cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0.5 mg/kg). Anesthetic parameters (heart rate, blood pressure [systolic (SAP), diastolic (DAP), and mean (MAP) blood pressure], body temperature, respiratory rate, and %SpO2) were monitored prior to and every 10 min (through 60 min) post atipamezole injection.
Results: While heart rate was significantly increased for 60 min; SAP, DAP, MAP, and temperature were significantly decreased at 10 min.
Conclusions: This study indicates subcutaneous atipamezole results in increased heart rate and transient blood pressure decrease. These findings are clinically important to ensure anesthetist awareness to properly support and treat patients as needed.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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