Early-life origin of prostate cancer through deregulation of miR-206 networks in maternally malnourished offspring rats.

Autor: Portela LMF; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Constantino FB; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Camargo ACL; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Santos SAA; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.; Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA., Colombelli KT; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Fioretto MN; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Barata LA; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Silva EJR; Department of Biophysics and Pharmacology, Institute of Biosciences, Unesp, Botucatu, Brazil., Scarano WR; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Felisbino SL; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil., Moreno CS; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA., Justulin LA; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil. l.justulin@unesp.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Oct 31; Vol. 13 (1), pp. 18685. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1038/s41598-023-46068-1
Abstrakt: The Developmental Origins of Health and Disease (DOHaD) concept has provided the framework to assess how early life experiences can shape health and disease throughout the life course. While maternal malnutrition has been proposed as a risk factor for the developmental programming of prostate cancer (PCa), the molecular mechanisms remain poorly understood. Using RNA-seq data, we demonstrated deregulation of miR-206-Plasminogen (PLG) network in the ventral prostate (VP) of young maternally malnourished offspring. RT-qPCR confirmed the deregulation of the miR-206-PLG network in the VP of young and old offspring rats. Considering the key role of estrogenic signaling pathways in prostate carcinogenesis, in vitro miRNA mimic studies also revealed a negative correlation between miR-206 and estrogen receptor α (ESR1) expression in PNT2 cells. Together, we demonstrate that early life estrogenization associated with the deregulation of miR-206 networks can contribute to the developmental origins of PCa in maternally malnourished offspring. Understanding the molecular mechanisms by which early life malnutrition affects offspring health can encourage the adoption of a governmental policy for the prevention of non-communicable chronic diseases related to the DOHaD concept.
(© 2023. The Author(s).)
Databáze: MEDLINE
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