A Micrometric Transformer: Compositional Nanoshell Transformation of Fe 3+ -Trimesic-Acid Complex with Concomitant Payload Release in Cell-in-Catalytic-Shell Nanobiohybrids.

Autor: Park J; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea., Kim N; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea., Han SY; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea., Rhee SY; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea., Nguyen DT; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea., Lee H; Department of Chemistry, Hallym University, Chuncheon, 24252, Republic of Korea., Choi IS; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Republic of Korea.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jan; Vol. 11 (1), pp. e2306450. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1002/advs.202306450
Abstrakt: Nanoencapsulation of living cells within artificial shells is a powerful approach for augmenting the inherent capacity of cells and enabling the acquisition of extrinsic functions. However, the current state of the field requires the development of nanoshells that can dynamically sense and adapt to environmental changes by undergoing transformations in form and composition. This paper reports the compositional transformation of an enzyme-embedded nanoshell of Fe 3+ -trimesic acid complex to an iron phosphate shell in phosphate-containing media. The cytocompatible transformation allows the nanoshells to release functional molecules without loss of activities and biorecognition, while preserving the initial shell properties, such as cytoprotection. Demonstrations include the lysis and killing of Escherichia coli by lysozyme, and the secretion of interleukin-2 by Jurkat T cells in response to paracrine stimulation by antibodies. This work on micrometric Transformers will benefit the creation of cell-in-shell nanobiohybrids that can interact with their surroundings in active and adaptive ways.
(© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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