Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen.

Autor: Stroffolini G; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy.; Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy., Lazzaro A; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy.; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Barco A; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy.; Department of Infectious Diseases, Novara Hospital, Novara, Italy., Pirriatore V; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy., Vai D; Maria Vittoria Hospital, Unit of Neurology, Asl Città di Torino, Turin, Italy., Giaccone C; Maria Vittoria Hospital, Unit of Neurology, Asl Città di Torino, Turin, Italy., Nigra M; San Giovanni Bosco Hospital, Laboratory, Asl Città di Torino, Turin, Italy., Atzori C; Maria Vittoria Hospital, Laboratory, Asl Città di Torino, Turin, Italy., Trunfio M; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy., Bonora S; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy., Di Perri G G; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy., Calcagno A; Department of Medical Sciences, Infectious Diseases Unit, University of Turin, Turin, Italy. andrea.calcagno@unito.it.
Jazyk: angličtina
Zdroj: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2023 Dec; Vol. 18 (4), pp. 551-562. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1007/s11481-023-10086-7
Abstrakt: The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in CSF biomarkers, Fibroscan and IMT measurements in PLWH with HAND randomized to a less neurotoxic regimen, or continuing their treatment. Adult patients with HAND were screened and enrolled if presenting no major resistance associated mutations, no HIV viral replication, not on efavirenz or darunavir, with R5-tropic HIV and without major confounding conditions. Lumbar puncture, IMT and Fibroscan measurements were performed. After 1:1 randomization to a less neurotoxic regimen consisting of darunavir/cobicistat plus emtricitabine plus maraviroc, or mantaining actual care, tests were repeated after 24 weeks: CSF biomarkes (HIV RNA, tau, p-tau, Beta-amyloid 1-42 , S100Beta and neopterin) were included. Non-parametric tests (Mann-Whitney and Wilcoxon's) were used. 28 participants completed the study. Male and European ancestry were prevalent; median age was 55 years (51-60). All patients were virally suppressed; median CD4 + count was 626 cell/uL (469-772). Baseline characteristics were similar between the study arms. A significant decrease in CSF p-tau and an increase in CSF neopterin and NFL were observed. We observed a significant reduction in liver stiffness at W24. Despite a small sample size we observed changes in neuromarkers and in hepatic stiffness in patients randomized to the experimental arm. We observed changes in CSF biomarkers (lower phosphorylated-tau and higher neopterin and NFL) that need to be replicated in large cohorts. Subclinical neurotoxicity may be observed in patients with HAND and warrants prospective studies.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: