Complete genome reconstruction of the global and European regional dispersal history of the lumpy skin disease virus.

Autor:	Van Borm S; Scientific Directorate Animal Infectious Diseases, Sciensano , Brussels, Belgium., Dellicour S; Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles , Brussels, Belgium.; Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven , Leuven, Belgium., Martin DP; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town , Cape Town, South Africa., Lemey P; Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven , Leuven, Belgium., Agianniotaki EI; National Reference Laboratory for Capripoxviruses, Department of Molecular Diagnostics, FMD, Virological, Rickettsial and Exotic Diseases, Directorate of Athens Veterinary Center, Ministry of Rural Development and Food , Athens, Greece., Chondrokouki ED; National Reference Laboratory for Capripoxviruses, Department of Molecular Diagnostics, FMD, Virological, Rickettsial and Exotic Diseases, Directorate of Athens Veterinary Center, Ministry of Rural Development and Food , Athens, Greece., Vidanovic D; Department for laboratory diagnostics, Veterinary Specialized Institute , Kraljevo, Serbia., Vaskovic N; Department for laboratory diagnostics, Veterinary Specialized Institute , Kraljevo, Serbia., Petroviċ T; Department for Virology, Scientific Veterinary Institute , Novi Sad, Serbia., Laziċ S; Department for Virology, Scientific Veterinary Institute , Novi Sad, Serbia., Koleci X; Faculty of Veterinary Medicine, The Agricultural University of Tirana , Tirana, Albania., Vodica A; Animal Health Department, Food Safety and Veterinary Institute , Tirana, Albania., Djadjovski I; Faculty of Veterinary Medicine, Ss. Cyril and Methodius University in Skopje , Skopje, Macedonia., Krstevski K; Faculty of Veterinary Medicine, Ss. Cyril and Methodius University in Skopje , Skopje, Macedonia., Vandenbussche F; Scientific Directorate Animal Infectious Diseases, Sciensano , Brussels, Belgium., Haegeman A; Scientific Directorate Animal Infectious Diseases, Sciensano , Brussels, Belgium., De Clercq K; Scientific Directorate Animal Infectious Diseases, Sciensano , Brussels, Belgium., Mathijs E; Scientific Directorate Animal Infectious Diseases, Sciensano , Brussels, Belgium.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2023 Nov 30; Vol. 97 (11), pp. e0139423. Date of Electronic Publication: 2023 Oct 31.
DOI:	10.1128/jvi.01394-23
Abstrakt:	Importance: Lumpy skin disease virus (LSDV) has a complex epidemiology involving multiple strains, recombination, and vaccination. Its DNA genome provides limited genetic variation to trace outbreaks in space and time. Sequencing of LSDV whole genomes has also been patchy at global and regional scales. Here, we provide the first fine-grained whole genome sequence sampling of a constrained LSDV outbreak (southeastern Europe, 2015-2017), which we analyze along with global publicly available genomes. We formally evaluate the past occurrence of recombination events as well as the temporal signal that is required for calibrating molecular clock models and subsequently conduct a time-calibrated spatially explicit phylogeographic reconstruction. Our study further illustrates the importance of accounting for recombination events before reconstructing global and regional dynamics of DNA viruses. More LSDV whole genomes from endemic areas are needed to obtain a comprehensive understanding of global LSDV dispersal dynamics. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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