UVC-Protective Activity of Lemongrass Among 12 Fat-soluble Herbal Extracts: Rapid Decay Due to Cytotoxicity.
| Autor: | Otaka Y; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan; y-ohtaka@dent.meikai.ac.jp sakagami@dent.meikai.ac.jp., Izawa M; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan., Sakagami H; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan., Shiba N; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan., Takahashi N; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan., Tanuma SI; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan., Amano S; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan., Uota S; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan., Inomata M; Division of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Saitama, Japan., Yokose S; Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan., Sunaga K; Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan., Hayashi S; Green Flask Laboratory, Tokyo, Japan., Koga-Ogawa Y; Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan., Nakaya G; Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan., Kito S; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | In vivo (Athens, Greece) [In Vivo] 2023 Nov-Dec; Vol. 37 (6), pp. 2464-2472. |
| DOI: | 10.21873/invivo.13353 |
| Abstrakt: | Background/aim: The COVID-19 pandemic led to the rapid spread of the use of ultraviolet C (UVC) sterilizers in many public facilities. Considering the harmful effects of prolonged exposure to UVC, manufacturing of safe skin care products is an important countermeasure. In continuation of our recent study of water-soluble herbal extracts, the present study aimed at searching for anti-UVC components from fat-soluble herbal extracts. Materials and Methods: Human dermal fibroblast and melanoma cells were exposed to UVC (1.193 W/m 2 ) for 3 min. Viable cell number was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell-cycle analysis was performed using a cell sorter. UVC-protective activity was quantified by the selective index (SI), i.e., the ratio of the 50% cytotoxic concentration for unirradiated cells to the concentration that restored viability of UVC-treated cells by 50%. Results: Only lemongrass extract, among 12 fat-soluble herbal extracts, showed significant anti-UVC activity, comparable to that of lignified materials and tannins, but exceeding that of N-acetyl-L-cysteine and resveratrol. Lemongrass extract was highly cytotoxic, producing a subG Conclusion: Removal of cytotoxic principle(s) from lemongrass extract is crucial to producing long-lasting UVC-protective effects. (Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
| Databáze: | MEDLINE |
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