Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer.
| Autor: | Meuten TK; Colorado State University, Fort Collins, CO., Dean GA; Colorado State University, Fort Collins, CO., Thamm DH; Colorado State University, Fort Collins, CO. |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary pathology [Vet Pathol] 2024 May; Vol. 61 (3), pp. 339-356. Date of Electronic Publication: 2023 Oct 31. |
| DOI: | 10.1177/03009858231207021 |
| Abstrakt: | Tumors in dogs and humans share many similar molecular and genetic features, incentivizing a better understanding of canine neoplasms not only for the purpose of treating companion animals, but also to facilitate research of spontaneously developing tumors with similar biologic behavior and treatment approaches in an immunologically competent animal model. Multiple tumor types of both species have similar dysregulation of signal transduction through phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB; AKT), and mechanistic target of rapamycin (mTOR), collectively known as the PI3K-AKT-mTOR pathway. This review aims to delineate the pertinent aspects of the PI3K-AKT-mTOR signaling pathway in health and in tumor development. It will then present a synopsis of current understanding of PI3K-AKT-mTOR signaling in important canine cancers and advancements in targeted inhibitors of this pathway. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: DHT has received research support from and is a shareholder in VetDC, which owns the rights to VDC-597. |
| Databáze: | MEDLINE |
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