Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score.

Autor: Silva MA; Faculty of Nutrition, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil., Resende CMM; Departament of Nutrition, Universidade Federal de Lavras, Trevo Rotatória Professor Edmir Sá Santos CEP: 37203-202, Lavras, Brazil., Louro MB; Department of Maternal Child and Public Health, School of Nursing, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Ribeiro SAV; Department of Nutrition and Health, Universidade Federal de Viçosa (UFV), Viçosa, Brazil., do Carmo Castro Franceschini S; Department of Nutrition and Health, Universidade Federal de Viçosa (UFV), Viçosa, Brazil., Velasquez-Melendez G; Department of Maternal Child and Public Health, School of Nursing, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Alvarez-Leite JI; Biochemistry and Immunology Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Durso DF; Department of Neurology, Wellstone Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA., de Novaes JF; Department of Nutrition and Health, Universidade Federal de Viçosa (UFV), Viçosa, Brazil.
Jazyk: angličtina
Zdroj: Nutrition bulletin [Nutr Bull] 2023 Dec; Vol. 48 (4), pp. 559-571. Date of Electronic Publication: 2023 Oct 31.
DOI: 10.1111/nbu.12644
Abstrakt: Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the association between the FTO (rs9939609), MC4R (rs17782313) and MTMR9 (rs2293855) polymorphisms, the obesity-related genetic risk score and atherogenic risk in Brazilian children. This is a cross-sectional study conducted in 544 children aged 4-9 years in the city of Viçosa, Minas Gerais state, Brazil. The single nucleotide polymorphisms rs9939609, rs17782313 and rs2293855, were identified by the system TaqMan SNP genotyping and the obesity-related genetic risk score was determined. The lipid profile (serum total cholesterol [TC], high density lipoprotein [HDL] cholesterol, low density lipoprotein [LDL] cholesterol, triglycerides) was analysed and the atherogenic indices (Castelli I and II indices), atherogenic coefficient (AC), lipoprotein combined index (LCI) and plasma atherogenic index (PAI) were calculated. A semi-structured questionnaire was applied, obtaining data on the sociodemographic, economic and lifestyle characteristics of the children. Weight and height measurements were performed in all children, and body composition was evaluated by Dual-Energy X-ray Absorptiometry (DXA). 55.5% of the sample had dyslipidaemia, while 28.5% of the sample had at least one polymorphism and 2.2% had three polymorphisms. Children with the AG/AA genotypes in the rs2293855 polymorphism had lower HDL cholesterol levels and higher TC/HDL cholesterol, LDL/HDL cholesterol ratios and AC. Those with one or more polymorphisms (rs9939609, rs17782313 and rs2293855) in the genetic risk score had lower HDL cholesterol levels and higher TC/HDL cholesterol ratios, AC, LCI and PAI. In conclusion, the risk allele of the rs2293855 polymorphism and a higher obesity-related genetic risk score were positively associated with higher atherogenic risk in Brazilian children.
(© 2023 British Nutrition Foundation.)
Databáze: MEDLINE
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