Characteristics and outcomes of patients with atrial versus ventricular secondary tricuspid regurgitation undergoing tricuspid transcatheter edge-to-edge repair - Results from the TriValve registry.

Autor: Russo G; Department of Biomedicine and Prevention, Cardiology Unit, Policlinico Tor Vergata, University of Rome, Rome, Italy., Badano LP; Department of Medicine and Surgery, University Milano Bicocca, Milan, Italy.; Department of Cardiology, Auxologico IRCCS, Milan, Italy., Adamo M; Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Alessandrini H; Department of Cardiology, Asklepios clinic Sankt Georg, Hamburg, Germany., Andreas M; Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria., Braun D; Medical Clinic and Polyclinic I, University Hospital of Munich, Munich, Germany., Connelly KA; Division of Cardiology, Toronto Heart Center, St. Michael's Hospital, Toronto, ON, Canada., Denti P; Division of Cardiology and Department of Cardiac Surgery, San Raffaele University Hospital, Milan, Italy., Estevez-Loureiro R; Interventional Cardiology Clinic, University Hospital Alvaro Cunqueiro, Vigo, Spain., Fam N; Division of Cardiology, Toronto Heart Center, St. Michael's Hospital, Toronto, ON, Canada., Gavazzoni M; Department of Medicine and Surgery, University Milano Bicocca, Milan, Italy.; Department of Cardiology, Auxologico IRCCS, Milan, Italy., Hahn RT; Division of Cardiology, Columbia University Medical Center-NewYork Presbyterian Hospital, New York, NY, USA., Harr C; Department of Cardiology, Asklepios clinic Sankt Georg, Hamburg, Germany., Hausleiter J; Medical Clinic and Polyclinic I, University Hospital of Munich, Munich, Germany., Himbert D; Division of Cardiology, Bichat Hospital, Paris, France., Kalbacher D; Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany., Ho E; Division of Cardiology, Montefiore Medical Center, New York, NY, USA., Latib A; Division of Cardiology, Montefiore Medical Center, New York, NY, USA., Lubos E; Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany., Ludwig S; Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany., Lurz P; Heart Center Leipzig at University of Leipzig, Leipzig, Germany., Monivas V; Division of Cardiology, Puerta de Hierro University Hospital, Madrid, Spain., Nickenig G; Heart center University of Bonn, Bonn, Germany., Pedicino D; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Pedrazzini G; Division of Cardiology, Cardiocentro Ticino Institute, EOC, Lugano, Switzerland.; Biomedical Faculty, Università della Svizzera Italiana (USI), Lugano, Switzerland., Pozzoli A; Division of Cardiac Surgery, Cardiocentro Ticino Institute EOC, Lugano, Switzerland., Pires Marafon D; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy., Pastorino R; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Praz F; Department of Cardiology, Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland., Rodes-Cabau J; Quebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada., Besler C; Heart Center Leipzig at University of Leipzig, Leipzig, Germany., Schofer J; Department of Cardiology, Asklepios clinic Sankt Georg, Hamburg, Germany., Scotti A; Division of Cardiology, Montefiore Medical Center, New York, NY, USA., Piayda K; CardioVascular Center Frankfurt CVC, Frankfurt, Germany., Sievert H; CardioVascular Center Frankfurt CVC, Frankfurt, Germany., Tang GHL; Department of Cardiovascular Surgery, Mount Sinai Health System, New York, NY, USA., Thiele H; Heart Center Leipzig at University of Leipzig, Leipzig, Germany., Schlotter F; Heart Center Leipzig at University of Leipzig, Leipzig, Germany., von Bardeleben RS; Division of Cardiology, University Medical Center, Mainz, Germany., Webb J; St. Paul Hospital, Vancouver, BC, Canada., Windecker S; Department of Cardiology, Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland., Leon M; Division of Cardiology, Columbia University Medical Center-NewYork Presbyterian Hospital, New York, NY, USA., Maisano F; Division of Cardiology and Department of Cardiac Surgery, San Raffaele University Hospital, Milan, Italy., Metra M; Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Taramasso M; HerzZentrum Hirslanden, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: European journal of heart failure [Eur J Heart Fail] 2023 Dec; Vol. 25 (12), pp. 2243-2251. Date of Electronic Publication: 2023 Nov 08.
DOI: 10.1002/ejhf.3075
Abstrakt: Aim: Functional or secondary tricuspid regurgitation (STR) is the most common phenotype of tricuspid regurgitation (TR) with atrial STR (ASTR) and ventricular STR (VSTR) being recently identified as two distinct entities. Data on tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with STR according to phenotype (i.e. ASTR vs. VSTR) are lacking. The aim of this study was to assess characteristics and outcomes of patients with ASTR versus VSTR undergoing T-TEER.
Methods and Results: Patients with STR undergoing T-TEER were selected from the Transcatheter Tricuspid Valve Therapies (TriValve) registry. ASTR was defined by (i) left ventricular ejection fraction ≥50%, (ii) atrial fibrillation, and (iii) systolic pulmonary artery pressure <50 mmHg. Patients not matching these criteria were classified as VSTR. Patients with primary TR and cardiac implantable electronic device were excluded. Key endpoints included procedural success and survival at follow-up. A total of 298 patients were enrolled in the study: 65 (22%) with ASTR and 233 (78%) with VSTR. Procedural success was similar in the two groups (80% vs. 83% for ASTR vs. VSTR, p = 0.56) and TEER was effective in reducing TR in both groups (from 97% of patients with baseline TR ≥3+ to 23% in ASTR and to 15% in VSTR, all p = 0.001). At 12-month follow-up, survival was significantly higher in the ASTR versus VSTR cohort (91% vs. 72%, log-rank p = 0.02), with VSTR being an independent predictor of mortality at multivariable analysis (hazard ratio 4.75).
Conclusions: In a real-world, multicentre registry, T-TEER was effective in reducing TR grade in both ASTR and VSTR. At 12-month follow-up, ASTR showed better survival than VSTR.
(© 2023 European Society of Cardiology.)
Databáze: MEDLINE
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