Exposure to urban nanoparticles at low PM[Formula: see text] concentrations as a source of oxidative stress and inflammation.

Autor: Costabile F; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Fosso del Cavaliere, 00133 Rome, Italy.; National Biodiversity Future Center, NBFC, 90133 Palermo, Italy., Gualtieri M; Department of Earth and Environmental Sciences, University of Milano-Bicocca, 26126 Milan, Italy., Rinaldi M; National Biodiversity Future Center, NBFC, 90133 Palermo, Italy.; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Gobetti, 40129 Bologna, Italy., Canepari S; Department of Environmental Biology, University of Rome Sapienza, 00185 Rome, Italy., Vecchi R; Department of Physics, Università degli Studi di Milano,and INFN-Milan, 20133 Milan, Italy., Massimi L; Department of Environmental Biology, University of Rome Sapienza, 00185 Rome, Italy., Di Iulio G; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Fosso del Cavaliere, 00133 Rome, Italy., Paglione M; National Biodiversity Future Center, NBFC, 90133 Palermo, Italy.; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Gobetti, 40129 Bologna, Italy., Di Liberto L; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Fosso del Cavaliere, 00133 Rome, Italy., Corsini E; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy., Facchini MC; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Gobetti, 40129 Bologna, Italy., Decesari S; National Biodiversity Future Center, NBFC, 90133 Palermo, Italy.; Institute of Atmospheric Sciences and Climate - Italian National Research Council (ISAC - CNR), Via Gobetti, 40129 Bologna, Italy.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Oct 30; Vol. 13 (1), pp. 18616. Date of Electronic Publication: 2023 Oct 30.
DOI: 10.1038/s41598-023-45230-z
Abstrakt: Exposures to fine particulate matter (PM[Formula: see text]) have been associated with health impacts, but the understanding of the PM[Formula: see text] concentration-response (PM[Formula: see text]-CR) relationships, especially at low PM[Formula: see text], remains incomplete. Here, we present novel data using a methodology to mimic lung exposure to ambient air (2[Formula: see text] 60 [Formula: see text]g m[Formula: see text]), with minimized sampling artifacts for nanoparticles. A reference model (Air Liquid Interface cultures of human bronchial epithelial cells, BEAS-2B) was used for aerosol exposure. Non-linearities observed in PM[Formula: see text]-CR curves are interpreted as a result of the interplay between the aerosol total oxidative potential (OP[Formula: see text]) and its distribution across particle size (d[Formula: see text]). A d[Formula: see text]-dependent condensation sink (CS) is assessed together with the distribution with d[Formula: see text] of reactive species . Urban ambient aerosol high in OP[Formula: see text], as indicated by the DTT assay, with (possibly copper-containing) nanoparticles, shows higher pro-inflammatory and oxidative responses, this occurring at lower PM[Formula: see text] concentrations (< 5 [Formula: see text]g m[Formula: see text]). Among the implications of this work, there are recommendations for global efforts to go toward the refinement of actual air quality standards with metrics considering the distribution of OP[Formula: see text] with d[Formula: see text] also at relatively low PM[Formula: see text].
(© 2023. The Author(s).)
Databáze: MEDLINE
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