Ferritinophagy: A new idea for liver diseases regulated by ferroptosis.

Autor: Qian ZB; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China., Li JF; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; Institute of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, China., Xiong WY; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China., Mao XR; The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; Department of Infectious Disease, The First Hospital of Lanzhou University, Lanzhou 730000, China. Electronic address: mxr2013@126.com.
Jazyk: angličtina
Zdroj: Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2024 Apr; Vol. 23 (2), pp. 160-170. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1016/j.hbpd.2023.10.005
Abstrakt: Background: The discovery of regulatory cell death has led to a breakthrough in the therapeutic field. Various forms of cell death, such as necrosis, apoptosis, pyroptosis, autophagy, and ferroptosis, play an important role in the development of liver diseases. In general, more than one form of cell death pathways is responsible for the disease state. Therefore, it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.
Data Sources: We performed a PubMed search up to November 2022 with the following keywords: ferritinophagy, ferroptosis, and liver disease. We also used terms such as signal path, inducer, and inhibitor to supplement the query results.
Results: This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.
Conclusions: Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: