An Electroconductive and Antibacterial Adhesive Nanocomposite Hydrogel for High-Performance Skin Wound Healing.

Autor: Zheng W; School of Chemistry, Chemical Engineering, and Life Sciences, Wuhan University of Technology, Wuhan, 430070, P. R. China., Yang W; School of Chemistry, Chemical Engineering, and Life Sciences, Wuhan University of Technology, Wuhan, 430070, P. R. China., Wei W; School of Chemistry, Chemical Engineering, and Life Sciences, Wuhan University of Technology, Wuhan, 430070, P. R. China., Liu Z; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, P. R. China., Tremblay PL; School of Chemistry, Chemical Engineering, and Life Sciences, Wuhan University of Technology, Wuhan, 430070, P. R. China.; Sanya Science and Education Innovation Park, Wuhan University of Technology, Sanya, 572024, P. R. China.; Shaoxing Institute for Advanced Research, Wuhan University of Technology, Shaoxing, 312300, P. R. China., Zhang T; School of Chemistry, Chemical Engineering, and Life Sciences, Wuhan University of Technology, Wuhan, 430070, P. R. China.; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, P. R. China.; Sanya Science and Education Innovation Park, Wuhan University of Technology, Sanya, 572024, P. R. China.; Shaoxing Institute for Advanced Research, Wuhan University of Technology, Shaoxing, 312300, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Mar; Vol. 13 (8), pp. e2303138. Date of Electronic Publication: 2023 Nov 12.
DOI: 10.1002/adhm.202303138
Abstrakt: Multifunctional hydrogel adhesives inhibiting infections and enabling the electrical stimulation (ES) of tissue reparation are highly desirable for the healing of surgical wounds and other skin injuries. Herein, a therapeutic nanocomposite hydrogel is designed by integrating β-cyclodextrin-embedded Ag nanoparticles ( CD AgNPs) in a polyvinyl alcohol (PVA) matrix enhanced with free β-cyclodextrin (CD) and an atypical macromolecule made of β-glucan grafted with hyaluronic acid (HAG). The main objective is to develop a biocompatible dressing combining the electroconductivity and antibacterial activity of CD AgNPs with the cohesiveness and porosity of PVA and the anti-inflammatory, moisturizing, and cell proliferation-promoting properties of HAG. The last component, CD, is added to strengthen the network structure of the hydrogel. PVA/CD/HAG/ CD AgNP exhibited excellent adhesion strength, biocompatibility, electroconductivity, and antimicrobial activity against a wide range of bacteria. In addition, the nanocomposite hydrogel has a swelling ratio and water retention capacity suitable to serve as a wound dressing. PVA/CD/HAG/ CD AgNP promoted the proliferation of fibroblast in vitro, accelerated the healing of skin wounds in an animal model, and is hemostatic. Upon ES, the PVA/CD/HAG/ CD AgNP nanocomposite hydrogel became more efficient both in vitro and in vivo further speeding up the skin healing process thus demonstrating its potential as a next-generation electroconductive wound dressing.
(© 2023 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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