LONG-TERM USE OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Autor:	Begaj T; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Jeong D; Oakland University William Beaumont, Rochester, Michigan., Park JG; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Runner MM; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Capone A Jr; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Dass AB; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Drenser KA; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Faia LJ; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Farley ND; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan., Garretson BR; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Hassan TS; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Mahmoud TH; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Margherio A; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan., Raphaelian PV; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan., Randhawa S; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Ruby AJ; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Sneed S; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Rao P; Retina and Vitreous of Texas, Houston, Texas., Wolfe JD; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan., Williams GA; Associated Retinal Consultants/Beaumont Health, Royal Oak, Michigan.; Oakland University William Beaumont, Rochester, Michigan.
Jazyk:	angličtina
Zdroj:	Retina (Philadelphia, Pa.) [Retina] 2024 Feb 01; Vol. 44 (2), pp. 222-229.
DOI:	10.1097/IAE.0000000000003961
Abstrakt:	Purpose: Although pivotal trials have demonstrated efficacy of anti-vascular endothelial growth factor therapy in neovascular age-related macular degeneration, there is a paucity of clinical data about the long-term (>5 years) treatment. Methods: Retrospective analysis of all patients with neovascular age-related macular degeneration who were actively treated, had received >40 anti-vascular endothelial growth factor injections, and were followed for ≥5 years. Snellen-corrected visual acuity, initial drug choice, and times elapsed between treatments were collected. Rates of endophthalmitis and outcomes of submacular hemorrhage were also evaluated. Results: A total of 88 patients (162 eyes) met the inclusion criteria: the average patient age was 86.3 years with an average follow-up period of 7.6 years. The average total number of injections per eye was 69 (18.0 SD); a total of 11,208 injections were given throughout the study period, and 6 cases (0.05%) of endophthalmitis were observed. Overall, there was a clinical and statistical difference in average Snellen-corrected visual acuity at Injections #2,#3, #4, #5, #6, #10, and #20, as compared with baseline ( P = 0.03, P < 0.01, P = 0.02, P < 0.01, P = 0.01, P = 0.01, P < 0.01, respectively). Patients in the Snellen-corrected visual acuity subgroup 20/20 to 20/40 maintained vision until injection #30. Seven eyes experienced a visually significant submacular hemorrhage. Conclusion: This neovascular age-related macular degeneration cohort received on average eight anti-vascular endothelial growth factor injections per year for approximately 8 years; eyes with good (≥20/40) initial baseline vision maintained their visual acuity, whereas those with worse Snellen-corrected visual acuity (≤20/50) had a robust initial improvement that diminished with time. Most patients were maintained on the same initial drug of choice and the rate of endophthalmitis was low.
Databáze:	MEDLINE
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