The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam.

Autor: Jones NK; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Thu TNH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., de Alwis R; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Thompson C; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Tuyen HT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nhu TDH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Phat VV; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Trung PD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Lam PK; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Tien BTT; Hung Vuong Hospital, Hong Bang, Ho Chi Minh City, Vietnam., Tuyet HTD; Hung Vuong Hospital, Hong Bang, Ho Chi Minh City, Vietnam., Vi LL; The Hospital for Tropical Diseases, Vo Van Kiet, Ho Chi Minh City, Vietnam., Van Vinh Chau N; The Hospital for Tropical Diseases, Vo Van Kiet, Ho Chi Minh City, Vietnam., Le Thi Quynh N; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Baker S; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Oct 30; Vol. 17 (10), pp. e0011728. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023).
DOI: 10.1371/journal.pntd.0011728
Abstrakt: Background: Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species.
Methods: Participants were enrolled between the age of 12-36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA units (EU) with convalescent IgG titre >10.3 EU was taken as evidence of seroconversion between timepoints.
Results: A total of 3,498 serum samples were collected from 748 participants; 3,170 from the 634 participants that completed follow-up. Measures of anti-O IgG varied significantly by calendar month (p = 0.03). Estimated S. sonnei seroincidence was 21,451 infections per 100,000 population per year (95% CI 19,307-23,834), with peak incidence occurring at 12-18 months of age. Three baseline factors were independently associated with the likelihood of seroconversion; ever having breastfed (aOR 2.54, CI 1.22-5.26), history of prior hospital admission (aOR 0.57, CI 0.34-0.95), and use of a toilet spray-wash in the household (aOR 0.42, CI 0.20-0.89).
Conclusions: Incidence of S. sonnei exposure in Ho Chi Minh City is substantial, with significant reduction in the likelihood of exposure as age increases beyond 2 years.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Jones et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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