Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus .

Autor: Sawektreeratana N, Krachangchaeng C, Pittayanurak P, Betterley NM, Chairoungdua A, Wongpan A, Panvongsa W; Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Bangkok 10400, Thailand., Janthakit P; Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong 21210, Thailand., Nalaoh P; Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, United States., Promarak V; Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong 21210, Thailand., Nuntasaen N, Reutrakul V, Kuhakarn C, Hongthong S; Division of Chemistry, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao 24000, Thailand.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2023 Nov 24; Vol. 25 (46), pp. 8183-8187. Date of Electronic Publication: 2023 Oct 30.
DOI: 10.1021/acs.orglett.3c02641
Abstrakt: The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C ( 1 - 3 , respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC 50 values ranging from 0.60 to 4.02 nM.
Databáze: MEDLINE