Diversity and evolution of an abundant ICE clc family of integrative and conjugative elements in Pseudomonas aeruginosa .

Autor:	Benigno V; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland., Carraro N; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland., Sarton-Lohéac G; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland., Romano-Bertrand S; Hydrosciences Montpellier, IRD, CNRS, University of Montpellier, Hospital Hygiene and Infection Control Team, University Hospital of Montpellier, Montpellier, France., Blanc DS; Prevention and Infection Control Unit, Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., van der Meer JR; Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Jazyk:	angličtina
Zdroj:	MSphere [mSphere] 2023 Dec 20; Vol. 8 (6), pp. e0051723. Date of Electronic Publication: 2023 Oct 30.
DOI:	10.1128/msphere.00517-23
Abstrakt:	Importance: Microbial populations swiftly adapt to changing environments through horizontal gene transfer. While the mechanisms of gene transfer are well known, the impact of environmental conditions on the selection of transferred gene functions remains less clear. We investigated ICEs, specifically the ICE clc -type, in Pseudomonas aeruginosa clinical isolates. Our findings revealed co-evolution between ICEs and their hosts, with ICE transfers occurring within strains. Gene functions carried by ICEs are positively selected, including potential virulence factors and heavy metal resistance. Comparison to publicly available P. aeruginosa genomes unveiled widespread antibiotic-resistance determinants within ICE clc clades. Thus, the ubiquitous ICE clc family significantly contributes to P. aeruginosa 's adaptation and fitness in diverse environments. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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