Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma.

Autor: Grzegorczyk A; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland., Marczyńska Z; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland., Matkowski R; Departament of Oncology, Wrocław Medical University, Wrocław, Poland.; Lower Silesian Oncology, Pulmonology and Hematology Center, Wrocław, Poland., Ziętek M; Departament of Oncology, Wrocław Medical University, Wrocław, Poland.; Lower Silesian Oncology, Pulmonology and Hematology Center, Wrocław, Poland., Pietras W; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland., Latos-Grażyńska E; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland., Kałwak K; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland., Dachowska-Kałwak I; Department of Pediatric Stem Cell Transplantation, Hematology and Oncology, Wroclaw Medical University, Wrocław, Poland.
Jazyk: angličtina
Zdroj: Central-European journal of immunology [Cent Eur J Immunol] 2023; Vol. 48 (3), pp. 251-256. Date of Electronic Publication: 2023 Aug 30.
DOI: 10.5114/ceji.2023.130864
Abstrakt: This study presents a case of a 17-year-old female patient who had previously undergone surgical resection of melanoma in the right periscapular area. She was administered adjuvant treatment with the PD-1 inhibitor nivolumab as monotherapy. The mechanism of action of this drug is based on increased stimulation of the immune system. The patient developed a series of complications including capillary leak syndrome and hypothyroidism after the fifth cycle of therapy, as a result of dysregulation of immunity. Nivolumab treatment had to be discontinued and glucocorticosteroids were administered as a salvage therapy. After several months, two relapses developed in the subcutaneous tissue - first in the left and then in the right iliac region, confirmed as distant metastases of malignant melanoma, treated with resections of the lesions and intensity-modulated radiation therapy. Follow-up imaging studies and clinical examinations showed no metastases or pathologically enlarged lymph nodes.
Competing Interests: The authors declare no conflict of interest.
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Databáze: MEDLINE
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