Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis .

Autor:	Oswald IWH; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Paryani TR; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Sosa ME; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States.; Chemistry and Biochemistry Department, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, California 91768, United States., Ojeda MA; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Altenbernd MR; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Grandy JJ; Sepsolve Analytical Schauenburg Analytics, 826 King Street North Unit 15, Waterloo, Ontario N2J4G8, Canada., Shafer NS; Markes International-Schauenburg Analytics, 2355 Gold Meadow Drive, Gold River, California 95670, United States., Ngo K; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Peat JR 3rd; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Melshenker BG; 710 Labs, 8149 Santa Monica Boulevard Suite 298, Los Angeles, California 90046, United States., Skelly I; 710 Labs, 8149 Santa Monica Boulevard Suite 298, Los Angeles, California 90046, United States., Koby KA; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States., Page MFZ; Chemistry and Biochemistry Department, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, California 91768, United States., Martin TJ; Department of Research and Development, Abstrax Tech, 2661 Dow Avenue, Tustin, California 92618, United States.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Oct 12; Vol. 8 (42), pp. 39203-39216. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).
DOI:	10.1021/acsomega.3c04496
Abstrakt:	Cannabis sativa L. produces a wide variety of volatile secondary metabolites that contribute to its unique aroma. The major volatile constituents include monoterpenes, sesquiterpenes, and their oxygenated derivates. In particular, the compounds ß-myrcene, D-(+)-limonene, ß-caryophyllene, and terpinolene are often found in greatest amounts, which has led to their use in chemotaxonomic classification schemes and legal Cannabis sativa L. product labeling. While these compounds contribute to the characteristic aroma of Cannabis sativa L. and may help differentiate varieties on a broad level, their importance in producing specific aromas is not well understood. Here, we show that across Cannabis sativa L. varieties with divergent aromas, terpene expression remains remarkably similar, indicating their benign contribution to these unique, specific scents. Instead, we found that many minor, nonterpenoid compounds correlate strongly with nonprototypical sweet or savory aromas produced by Cannabis sativa L. Coupling sensory studies to our chemical analysis, we derive correlations between groups of compounds, or in some cases, individual compounds, that produce many of these diverse scents. In particular, we identified a new class of volatile sulfur compounds (VSCs) containing the 3-mercaptohexyl functional group responsible for the distinct citrus aromas in certain varieties and skatole (3-methylindole) as the key source of the chemical aroma in others. Our results provide not only a rich understanding of the chemistry of Cannabis sativa L. but also highlight how the importance of terpenes in the context of the aroma of Cannabis sativa L. has been overemphasized. Competing Interests: The authors declare the following competing financial interest(s): I.W.H.O., T. R. P., M.A.O., T.J.M., K. N., M. E. S., M. F. Z. P., and K.A.K. have filed patents related to the results described herein. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu