Analytical Methods for the Determination of Quercetin and Quercetin Glycosides in Pharmaceuticals and Biological Samples.

Autor: Mansour FR; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Tanta University, Tanta 31111, Egypt., Abdallah IA; Department of Analytical Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Monufia, Egypt., Bedair A; Department of Analytical Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Monufia, Egypt., Hamed M; School of Information Technology and Computer Science (ITCS), Nile University, Giza, Egypt.
Jazyk: angličtina
Zdroj: Critical reviews in analytical chemistry [Crit Rev Anal Chem] 2023 Oct 29, pp. 1-26. Date of Electronic Publication: 2023 Oct 29.
DOI: 10.1080/10408347.2023.2269421
Abstrakt: Flavonoids are plant-derived compounds that have several health benefits, including antioxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic effects. Quercetin is a flavonoid that is widely present in various fruits, vegetables, and drinks. Accurate determination of quercetin in different samples is of great importance for its potential health benefits. This review, is an overview of sample preparation and determination methods for quercetin in diverse matrices. Previous research on sample preparation and determination methods for quercetin are summarized, highlighting the advantages and disadvantages of each method and providing insights into recent developments in quercetin sample treatment. Various analytical techniques are discussed including spectroscopic, chromatographic, electrophoretic, and electrochemical methods for the determination of quercetin and its derivatives in different samples. UV-Vis (Ultraviolet-visible) spectrophotometry is simple and inexpensive but lacks selectivity. Chromatographic techniques (HPLC, GC) offer selectivity and sensitivity, while electrophoretic and electrochemical methods provide high resolution and low detection limits, respectively. The aim of this review is to comprehensively explore the determination methods for quercetin and quercetin glycosides in diverse matrices, with emphasis on pharmaceutical and biological samples. The review also provides a theoretical basis for method development and application for the analysis of quercetin and quercetin glycosides in real samples.
Databáze: MEDLINE