Bacterial second messenger cyclic di-AMP in streptococci.

Autor: Wright MJ; Department of Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA., Bai G; Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Jazyk: angličtina
Zdroj: Molecular microbiology [Mol Microbiol] 2023 Dec; Vol. 120 (6), pp. 791-804. Date of Electronic Publication: 2023 Oct 28.
DOI: 10.1111/mmi.15187
Abstrakt: Cyclic dimeric adenosine monophosphate (c-di-AMP) has been well studied in bacteria, including those of the genus Streptococcus, since the first recognition of this dinucleotide in 2008. Streptococci possess a sole diadenylate cyclase, CdaA, and distinct c-di-AMP phosphodiesterases. Interestingly, cdaA is required for viability of some streptococcal species but not all when streptococci are grown in standard laboratory media. Bacteria of this genus also have distinct c-di-AMP effector proteins, diverse c-di-AMP-signaling pathways, and subsequent biological outcomes. In streptococci, c-di-AMP may influence bacterial growth, morphology, biofilm formation, competence program, drug resistance, and bacterial pathogenesis. c-di-AMP secreted by streptococci has also been shown to interact with the mammalian host and induces immune responses including type I interferon production. In this review, we summarize the reported c-di-AMP networks in seven species of the genus Streptococcus, which cause diverse clinical manifestations, and propose future perspectives to investigate the signaling molecule in these streptococcal pathogens.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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