Calcium transport and sensing in TRPC channels - New insights into a complex feedback regulation.

Autor: Baron J; Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria., Groschner K; Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria., Tiapko O; Gottfried-Schatz-Research-Center Medical Physics and Biophysics, Medical University of Graz, Neue Stiftingtalstrasse 6/H03, 8010 Graz, Austria. Electronic address: oleksandra.tiapko@medunigraz.at.
Jazyk: angličtina
Zdroj: Cell calcium [Cell Calcium] 2023 Dec; Vol. 116, pp. 102816. Date of Electronic Publication: 2023 Oct 18.
DOI: 10.1016/j.ceca.2023.102816
Abstrakt: Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca 2+ influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory- and recently uncovered structural features, TRPC channels are considered to coordinate Ca 2+ and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.
Competing Interests: Declaration of Competing Interest There are no conflicts to declare.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: