The added value of lung perfusion scintigraphy semiquantitative measures in post-COVID patients with persistent dyspnea without pulmonary embolism.

Autor:	Lanfranchi F; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Maggio S; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Delucchi C; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Bertoldi F; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Corica F; Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy., De Feo MS; Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy., Marini C; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; CNR Institute of Molecular Bioimaging and Physiology, Milan, Italy., Aloè T; Interventional Pulmonology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Frantellizzi V; Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy., De Vincentis G; Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy., Morbelli S; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Sambuceti G; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Barisione E; Interventional Pulmonology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Bauckneht M; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Jazyk:	angličtina
Zdroj:	Expert review of medical devices [Expert Rev Med Devices] 2023 Jul-Dec; Vol. 20 (12), pp. 1243-1249. Date of Electronic Publication: 2023 Nov 24.
DOI:	10.1080/17434440.2023.2277236
Abstrakt:	Background: Persistent dyspnea is frequent in post-COVID patients, even in the absence of pulmonary embolism (PE). In this scenario, the role of lung perfusion scintigraphy is unclear. The present study correlated scintigraphy-based semiquantitative perfusion parameters with chest high-resolution computed tomography (hrCT) volumetric indexes and clinical data in post-COVID patients with persistent dyspnea. Research Design and Methods: Sixty patients (30 post-COVID and 30 not previously affected by COVID-19) with persistent dyspnea submitted to lung perfusion scintigraphy and hrCT were retrospectively recruited. Perfusion rates of the pulmonary fields and hrCT-based normalized inflated, emphysematous, infiltrated, collapsed, and vascular lung volumes were calculated. Inflammatory and coagulation biomarkers were collected. PE at imaging was an exclusion criterion. Results: Compared to controls, reduced perfusion rates of the lower pulmonary fields and higher perfusion rates of the middle ones were observed in post-COVID patients, while hrCT findings were superimposable between the two groups. Perfusion rates of lower pulmonary fields were significantly associated only with abnormal lung volumes at hrCT. Conclusions: In post-COVID dyspnea without PE, lung perfusion scintigraphy may reveal a pulmonary involvement not detectable by hrCT. Post-COVID patients may show decreased perfusion rates of lower pulmonary fields in the presence of normal vascular density and markers of inflammation/coagulation.
Databáze:	MEDLINE
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