Lanthanide Mimicking by Magnesium for Oxazolidinone Synthesis.

Autor: Kumar R; Inorganic Chemistry and Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Mahata B; Inorganic Chemistry and Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Gayathridevi S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India., Vipin Raj K; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India., Vanka K; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India., Sen SS; Inorganic Chemistry and Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, 411008, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jan 16; Vol. 30 (4), pp. e202303478. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1002/chem.202303478
Abstrakt: In the last decade, magnesium complexes have emerged as a viable alternative to transition-metal catalysts for the hydrofunctionalization of unsaturated bonds. However, their potential for advanced catalytic reactions has not been thoroughly investigated. To address this gap, we have developed a novel magnesium amide compound (3) using a PNP framework that is both bulky and flexible. Our research demonstrates that compound 3 can effectively catalyze the synthesis of biologically significant oxazolidinone derivatives. This synthesis involves a tandem reaction of hydroalkoxylation and cyclohydroamination of isocyanate using propargyl alcohol. Furthermore, we conducted comprehensive theoretical calculations to gain insights into the reaction mechanism. It is important to note that these types of transformations have not been reported for magnesium and would significantly enhance the catalytic portfolio of the 7th most abundant element.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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