Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon.

Autor:	Yala JF; Bacteriology Laboratory, Unity for Research Medical Analysis of the Interdisciplinary, Centre of Medical Research of Franceville (CIRMF), Franceville BP 769, Gabon.; Laboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon., Mabika Mabika R; Bacteriology Laboratory, Unity for Research Medical Analysis of the Interdisciplinary, Centre of Medical Research of Franceville (CIRMF), Franceville BP 769, Gabon.; Laboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon., Ikabanga DU; Laboratory of Plant Physiology, Phytopathology and Plant Breeding, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon., Mounioko F; Laboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon.; Unity for Research Health Ecology of the Interdisciplinary, Centre of Medical Research of Franceville (CIRMF), Franceville BP 769, Gabon., Mokouapamba PR; Laboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon., Lepengue AN; Laboratory of Plant Physiology, Phytopathology and Plant Breeding, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon., Souza A; Laboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, Gabon.; Laboratory of Animal Physiology and Pharmacology, Agrobiology Research Unit, Masuku University of Science and Technology (USTM), Franceville BP 067, Gabon.
Jazyk:	angličtina
Zdroj:	Plants (Basel, Switzerland) [Plants (Basel)] 2023 Oct 20; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 20.
DOI:	10.3390/plants12203629
Abstrakt:	Diarrhea is a condition that particularly affects children under five the age of years old in developing countries. The aim of this study was to evaluate the efficacy of medicinal extracts plants used in treatment and to characterize their inhibitory capacity in the growth of bacteria isolates in childhood diarrhea in the southeast region of Gabon. An ethnobotanical survey on the plants used in the treatment of diarrhea in southeastern Gabon was carried out and a phytochemical screening of the collected plants was performed. The antimicrobial activity of aqueous extracts was evaluated; 33 plant species were identified, representing 28 genera and 19 families. Bark (39.5%) was the most commonly used plant part, followed by powder formulations (28.9%). The preferred method of preparation and chewing (44.7%), together with drinking (36.8%), were the most prevalent modes of administration. Phytochemical screening showed a plethora of secondary metabolites (terpenoids, alkaloids and phenolic compounds), and a marked level of anti-diarrheal activity was found with Sida acuta and Santiria. ebo against Shigella spp. (16.22 ± 0.7 mm and 14.05 ± 1.4 mm) and Yersinia pestis (16.35 ± 0.5 mm and 15.51 ± 0.5 mm). The high diversity of secondary plant metabolites and their inhibitory ability against enteric pathogens would justify their use at the local level to treat diarrheal infections.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu