The Role of Carbon Ion Therapy in the Changing Oncology Landscape-A Narrative Review of the Literature and the Decade of Carbon Ion Experience at the Italian National Center for Oncological Hadrontherapy.

Autor: Orlandi E; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Barcellini A; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy.; Department of Internal Medicine and Medical Therapy, University of Pavia, 27100 Pavia, Italy., Vischioni B; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Fiore MR; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Vitolo V; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Iannalfi A; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Bonora M; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Chalaszczyk A; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Ingargiola R; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Riva G; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Ronchi S; Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Valvo F; Scientific Directorate, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Fossati P; Department of Radiation Oncology, MedAustron Ion Therapy Center, 2700 Wiener Neustadt, Austria.; Department for Basic and Translational Oncology and Haematology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria., Ciocca M; Medical Physics Unit, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy., Mirandola A; Medical Physics Unit, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy., Molinelli S; Medical Physics Unit, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy., Pella A; Bioengineering Unit, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy., Baroni G; Bioengineering Unit, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy., Pullia MG; Radiobiology Unit, Research and Development Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Facoetti A; Radiobiology Unit, Research and Development Department, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy., Orecchia R; Scientific Directorate, IEO-European Institute of Oncology, IRCCS, 20141 Milan, Italy., Licitra L; Scientific Directorate, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy.; Department of Head & Neck Medical Oncology 3, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.; Department of Oncology & Haemato-Oncology, University of Milan, 20122 Milan, Italy., Vago G; Presidency, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy.; School of Pathology, University of Milan, 20122 Milan, Italy., Rossi S; General Directorate, CNAO National Center for Oncological Hadrontherapy, 27100 Pavia, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Oct 20; Vol. 15 (20). Date of Electronic Publication: 2023 Oct 20.
DOI: 10.3390/cancers15205068
Abstrakt: Background: Currently, 13 Asian and European facilities deliver carbon ion radiotherapy (CIRT) for preclinical and clinical activity, and, to date, 55 clinical studies including CIRT for adult and paediatric solid neoplasms have been registered. The National Center for Oncological Hadrontherapy (CNAO) is the only Italian facility able to accelerate both protons and carbon ions for oncological treatment and research.
Methods: To summarise and critically evaluate state-of-the-art knowledge on the application of carbon ion radiotherapy in oncological settings, the authors conducted a literature search till December 2022 in the following electronic databases: PubMed, Web of Science, MEDLINE, Google Scholar, and Cochrane. The results of 68 studies are reported using a narrative approach, highlighting CNAO's clinical activity over the last 10 years of CIRT.
Results: The ballistic and radiobiological hallmarks of CIRT make it an effective option in several rare, radioresistant, and difficult-to-treat tumours. CNAO has made a significant contribution to the advancement of knowledge on CIRT delivery in selected tumour types.
Conclusions: After an initial ramp-up period, CNAO has progressively honed its clinical, technical, and dosimetric skills. Growing engagement with national and international networks and research groups for complex cancers has led to increasingly targeted patient selection for CIRT and lowered barriers to facility access.
Databáze: MEDLINE
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