Clinical and Epidemiological Aspects of Acute Q Fever in Reunion Island over Fourteen Years: A Retrospective Cohort Study.

Autor: Aubin A; Service des Maladies Infectieuses-Dermatologie, Centre Hospitalier Universitaire (CHU) Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Eldin C; Comité de Lutte Contre les Infections Nosocomiales (CLIN), Hôpital Nord, Chemin des Bourrély, 13015 Marseille, France.; Unité des Virus Emergents (UVE), Aix-Marseille Université, IRD 190 INSERM 1207 EFS-IRBA, 13005 Marseille, France., Zemali N; Laboratoire de Microbiologie, CHU Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Jaubert J; Laboratoire de Microbiologie, CHU Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Koumar Y; Service des Maladies Infectieuses-Dermatologie, Centre Hospitalier Universitaire (CHU) Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Moiton MP; Service des Maladies Infectieuses-Médecine Interne, CHU Réunion, 97400 Saint Denis, La Réunion, France., Poubeau P; Service des Maladies Infectieuses-Dermatologie, Centre Hospitalier Universitaire (CHU) Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Braunberger E; Service de Chirurgie Thoracique, CHU Réunion, 97400 Saint Denis, La Réunion, France., Gérardin P; Inserm CIC1410, CHU Réunion, BP 350, 97448 Saint Pierre, La Réunion, France., Bertolotti A; Service des Maladies Infectieuses-Dermatologie, Centre Hospitalier Universitaire (CHU) Réunion, BP 350, 97448 Saint Pierre, La Réunion, France.; Inserm CIC1410, CHU Réunion, BP 350, 97448 Saint Pierre, La Réunion, France.
Jazyk: angličtina
Zdroj: Microorganisms [Microorganisms] 2023 Oct 03; Vol. 11 (10). Date of Electronic Publication: 2023 Oct 03.
DOI: 10.3390/microorganisms11102485
Abstrakt: The clinical characteristics and epidemiology of Q fever in the Tropics are poorly described. We performed a retrospective cohort study of hospitalized cases between 2004 and 2017 in Reunion Island. Acute Q fever was defined in presence of a positive serology (phase II IgG ≥ 200 and phase II IgM ≥ 50), or a seroconversion (4-fold increase in phase II IgG between paired samples), or a positive PCR (blood or serum). Forty-two cases matched the diagnostic criteria. The most common clinical manifestations were fever (85.7%) and pulmonary symptoms (61.9%), including pneumonia (45.2%). Ninety percent of the patients were living in a farming area. Cumulative incidence was estimated at 9.3 per 100,000 inhabitants (95%CI: 6.4-12.1) with cases diagnosed yearly all throughout the study period except in 2006. Together with the seroprevalence figures, these data suggest that Q fever reaches low to moderate endemic levels on Reunion Island. As previously reported, pulmonary symptoms are in the foreground.
Databáze: MEDLINE
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