| Autor: |
Selvamani S; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia.; Nutrition Technologies SDN. BHD., No 1 & No 3, Jalan SiLC 2, Kawasan Perindustrian SiLC, Iskandar Puteri, Johor Bahru 80150, Malaysia.; Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia., Kapoor N; Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL 32806, USA., Ajmera A; Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL 32806, USA., El Enshasy HA; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia.; Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia.; City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria 21500, Egypt., Dailin DJ; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia.; Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 80000, Malaysia., Sukmawati D; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Rawamangun, Jakarta Timur 13530, Indonesia., Abomoelak M; Orange County Public School, Orlando, FL 32806, USA., Nurjayadi M; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Rawamangun, Jakarta Timur 13530, Indonesia., Abomoelak B; Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL 32806, USA.; Specialty Diagnostic Laboratory, Arnold Palmer Hospital for Children, Orlando, FL 32806, USA. |
| Abstrakt: |
At present, prebiotics, like probiotics, are receiving more attention as a promising tool for health maintenance. Many studies have recognized the role of prebiotics in preventing and treating various illnesses including metabolic disorders, gastrointestinal disorders, and allergies. Naturally, prebiotics are introduced to the human body in the first few hours of life as the mother breastfeeds the newborn. Prebiotic human milk oligosaccharides (HMOs) are the third largest constituent of human breastmilk. Studies have proven that HMOs modulate an infant's microbial composition and assist in the development of the immune system. Due to some health conditions of the mother or beyond the recommended age for breastfeeding, infants are fed with formula. Few types of prebiotics have been incorporated into formula to yield similar beneficial impacts similar to breastfeeding. Synthetic HMOs have successfully mimicked the bifidogenic effects of breastmilk. However, studies on the effectiveness and safety of consumption of these synthetic HMOs are highly needed before massive commercial production. With the introduction of solid foods after breastfeeding or formula feeding, children are exposed to a range of prebiotics that contribute to further shaping and maturing their gut microbiomes and gastrointestinal function. Therefore, this review evaluates the functional role of prebiotic interventions in improving microbial compositions, allergies, and functional gastrointestinal disorders in children. |
