| Autor: |
Grisoni Sanchez C; Institute of Health Sciences, Paulista University-UNIP, Bauru 17048-290, Brazil., Figueiredo ML; College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA., de Sartori Camargo L; School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18610-160, Brazil., Benevenuto LGD; School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18610-160, Brazil., Lacerda ZA; School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18610-160, Brazil., Fonseca-Alves CE; Institute of Health Sciences, Paulista University-UNIP, Bauru 17048-290, Brazil.; School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu 18610-160, Brazil.; Veterinary Oncology Clinic-SEOVET, São Paulo 05016-000, Brazil. |
| Abstrakt: |
Osteopontin (OPN) is a protein synthesized by a large number of cells, and its overexpression has been associated with the development and prognosis of cancer. OPN overexpression has been claimed to be a marker for the development of bone metastasis in human cancers, but no prior research has investigated the association between OPN expression and the metastasis of canine mammary gland tumors (MGTs) and prostate cancer (PC). Therefore, we investigated OPN expression in MGTs and PC samples from 50 canine patients with or without metastasis (bone vs. other sites). Higher OPN expression was detected in primary tumor samples from animals with bone metastasis than in those without bone involvement ( p = 0.0321). In MGT samples, a significantly lower survival rate was observed in patients with higher OPN expression ( p = 0.0171). In animals with PC, there was a strong trend toward lower survival in animals with positive OPN expression; however, this trend was not statistically significant ( p = 0.0779). From these findings, it can be concluded that OPN may be a promising target for future MGTs and PC studies because of its role in enhancing cell invasion and metastasis. |
