Endometrial Osseous Metaplasia-A Rare Cause of Infertility with Unknown Etiology.

Autor: Tica VI; Department of Obstetrics and Gynecology, 'Saint Andrew' University Emergency Hospital Constanta, Faculty of Medicine, Academy of Romanian Scientists University 'Ovidius', 900527 Constanta, Romania., Postolache I; Obstetrics and Gynecology, Euromaterna Hospital, 900402 Constanta, Romania., Boșoteanu M; Department of Pathology of 'Saint Andrew' University Emergency Hospital Constanta, Faculty of Medicine, University 'Ovidius', 900527 Constanta, Romania., Aschie M; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Faculty of Medicine, University 'Ovidius', 900591 Constanta, Romania., Tica I; Department of Internal Medicine of 'Saint Andrew' University Emergency Hospital Constanta, Faculty of Medicine, University 'Ovidius', 900470 Constanta, Romania., Orasanu CI; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Faculty of Medicine, University 'Ovidius', 900591 Constanta, Romania., Penciu RC; Department of Obstetrics and Gynecology, 'Saint Andrew' University Emergency Hospital Constanta, Faculty of Medicine, Academy of Romanian Scientists University 'Ovidius', 900527 Constanta, Romania., Tica AA; Department of Pharmacology, University of Medicine and Pharmacy, 200349 Craiova, Romania.; Department of Obstetrics and Gynecology, County Emergency Hospital, 200642 Craiova, Romania., Steriu L; Department of Obstetrics and Gynecology, 'Saint Andrew' University Emergency Hospital Constanta, Faculty of Medicine, Academy of Romanian Scientists University 'Ovidius', 900527 Constanta, Romania., De Wilde RL; 'Pius' Hospital Oldenburg, University Hospital for Gynecology, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany., Tica OS; Department of Obstetrics and Gynecology, County Emergency Hospital, 200642 Craiova, Romania.; Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 200642 Craiova, Romania.
Jazyk: angličtina
Zdroj: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Oct 10; Vol. 59 (10). Date of Electronic Publication: 2023 Oct 10.
DOI: 10.3390/medicina59101803
Abstrakt: Background: Osseous tissue in the endometrium is a rare find, and it is most often discovered when the patient presents with infertility. It is frequently associated with dysmenorrhea and abnormal menstrual bleedings. Although its etiology remains unclear, in almost all described cases until now, the patient has an obstetrical history. Case report : In this report, we present a unique case of endometrial osseous metaplasia in a 27-year-old primary infertile patient. The transvaginal ultrasound revealed a 18/13/7 mm hyperechoic endometrial mass with posterior acoustic shadowing and no flow on color Doppler. A hysteroscopic examination found a polygonal calcification on the endometrial posterior face of the uterine cavity, in the corporeal isthmic region, which was extracted. The histopathological evaluation revealed microscopic elements compatible with endometrial calcification. The patient had a good postoperative course and the complex endocrinologic, immunologic and electrolytical investigation failed to prove any abnormality. Follow-up transvaginal ultrasound examinations revealed no modifications. Three years later, the patient conceived spontaneously, had an uneventful pregnancy and delivered a full-term fetus. Conclusion : We assumed that this entity can be a serious cause of infertility since the patient had a long history of (primary) infertility and its resection made the pregnancy's occurrence possible. Finally, since neither history of abortion or chronic inflammation nor any abnormal laboratory test were noticed, we concluded that the etiology of this entity remained unclear.
Databáze: MEDLINE